Comment: An herb recently found to kill pancreatic cancer cells also appears to inhibit development of pancreatic cancer as a result of its anti-inflammatory properties, according to researchers from the Kimmel Cancer Center at Jefferson. The data were presented at the AACR 100th Annual Meeting 2009 in Denver. Thymoquinone, the major constituent of the oil extract from a Middle Eastern herbal seed called Nigella sativa, exhibited anti-inflammatory properties that reduced the release of inflammatory mediators in pancreatic cancer cells. Nigella sativa seeds and oil are used in traditional medicine by many Middle Eastern and Asian countries. It helps treat a broad array of diseases, including some immune and inflammatory disorders. The researchers used pancreatic ductal adenocarcinoma (PDA) cells, some of which were pretreated with the cytokine TNF-alpha to induce inflammation. Thymoquinone almost completely abolished the expression of several inflammatory cytokines, including TNF-alpha, interleukin-1beta, interleukin-8, Cox-2 and MCP-1. The herb also inhibited the activation and synthesis of NF-kappaB, a transcription factor that has been implicated in inflammation-associated cancer. Activation of NF-kappaB has been observed in pancreatic cancer and may be a factor in pancreatic cancer’s resistance to chemotherapeutic agents.

An Herbal Extract Inhibits the Development of Pancreatic Cancer
Reading Time: < 1 minutes
Recent Posts
- SCFAs and Skin Health June 28, 2022
- Bio Availability June 27, 2022
- Enzymes and Lipids – a Healthy Vasculature Can Make June 14, 2022
- The Guts of Health May 31, 2022
- Here’s the thing May 18, 2022
Recent Comments
- Leah Jamieson on Michael Ash: Probiotics – Sorting the ‘Wheat from the Chaff’
- Teresa Moussa on Michael Ash: Probiotics – Sorting the ‘Wheat from the Chaff’
- Claire Tozer on A Special Note from Garth Nicolson PhD Why Lipid Replacement Therapy(LRT®) is Key to our Health
- Candace Verona on A Special Note from Garth Nicolson PhD Why Lipid Replacement Therapy(LRT®) is Key to our Health
- Peter on Potent, Natural Fibrinolytic Enzymes Safely Reduce Clotting Risk
Tags
A(H1N1)
allergies
antibiotics
antioxidants
autism
autoimmune
bacteria
bias
brain
CAM
cancer
cardiovascular
coeliac
cytokines
depression
detoxification
diet
dysbiosis
EFAs
evidence
fatty acids
gut
gut health
IBD
IBS
immune
immunity
inflammation
microbiome
microbiota
mucosal
nutrition
obesity
pandemic
pregnancy
prevention
probiotics
regulatory T cells
research
swine flu
treatment
virus
Vitamin A
vitamin D
vitamins