Glandular Therapies: An Age-Old Solution for Modern Challenges and Chronic Disease

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UntitledLinda Isaacs, MD, Discusses Her Work with Nicholas Gonzalez, MD, and Her Use of Glandular Therapies in Her Practice

Learn the theories behind what makes glandular therapies successful, the importance of proper preparation, and some clinical uses for these substances from an expert in their use.

Linda L. Isaacs, MD, received her Bachelor of Science in Biochemistry from the University of Kentucky, graduating with High Distinction. After this she completed her medical training at the Vanderbilt University School of Medicine, doing her residency in internal medicine at the Department of Veterans Affairs Medical Center at New York University School of Medicine. She is certified by the American Board of Internal Medicine, completing the recertification process in 2001 and in 2011.

She met her long-time colleague Nicholas J. Gonzalez, MD, in 1983, and for more than 20 years, they worked in the same office, spoke daily about patient care, and collaborated on research projects. During this time, together they published multiple articles in scientific journals, as well as a book, The Trophoblast and the Origins of Cancer. Since Dr. Gonzalez’s untimely death in July 2015, Dr. Isaacs has dedicated herself to continuing the work they both shared. Her website is

An Interview from Allergy Researchs Focus Newsletter 2019

FOCUS: Tell us about your background and how you became interested in healing chronic disease with integrative and nutritional medicine. How did you become involved with Nicholas Gonzalez, MD, and the work he was doing with glandular therapies?

LLI: When I began my training as an undergraduate and while in medical school, I was a very conventional student. Much as many students in this era of life, I was eager to learn but I wasn’t thinking particularly outside the box. I was open-minded to the role nutrition and nutritional supplements may play in healing, as my mother developed an interest in nutrition after her symptoms of arthritis were relieved with the use of certain mineral therapies.

As a student in my undergraduate years, I worked in a biochemistry laboratory that was studying the protein alpha-1 antitrypsin. There, I learned the different theories and hypotheses at the time about how this protein might be involved in emphysema caused by smoking. However, a short time later when I was in my early years of medical school, we were told about the role alpha-1 antitrypsin played in lung damage from smoking as if it were a fact. I was very aware we were far from knowing this as a fact, so this led me to be more questioning of all the things I was being taught that were posed as black and white in nature.

As a 3rd year medical student, I met Dr. Gonzalez, who was simultaneously completing his medical internship and continuing his investigation of the work of William Donald Kelley, DDS, MS. Dr. Kelley was another early pioneer of glandular therapies who focused much of his career around treating patients with these substances after experiencing his own profound healing.[i] Dr. Gonzalez was learning about glandular therapies himself as he trained under Dr. Kelley. Around this time, I had become very sick with symptoms that resembled what we now call chronic fatigue syndrome or myalgic encephalomyelitis. In this era, we were far less aware of the possible dangers associated with things like chemical exposure—which I experienced in the biochemistry lab where I had worked. Under Dr. Gonzalez’s direction, I began taking glandular therapies to help me recover, and I found that over time my symptoms resolved. Having the opportunity to see these therapies work with not only patients but also myself made me even more convinced of their healing potential.

FOCUS: Can you give us a bit of background on what glandular therapies are, and the mechanisms by which they might work?

LLI: Glandular substances are specially treated preparations of the different animal-sourced glands, such as the pancreas, thyroid, or adrenal gland. There are a variety of glandular products that one might find in an exhaustive search; Dr. Gonzalez and I also went through the process of seeking out the optimal glandular supplements. The glandulars that we found to be most successful when working with our patients are prepared by a special freeze-drying technique that leaves everything that naturally occurs in the tissue, except for the water, still present. I have tried other glandular preparations and found that they really weren’t as effective or strong as these lyophilized glandulars.

When glandular substances are prepared in this fashion, we know they contain a variety of substances including nutrients, proteins, growth factors, and other cofactors found in the gland. These include enzymes that are normally found in pancreatic tissue, and vitamins and minerals that are found at high levels in the liver. Our understanding of how glandular therapies work is largely based on theory and clinical experience, but it boils down to four main concepts:

1) We are not eating the way our ancestors did, and most of us do not include organ meat in our diet. However, many people, including those who follow the work of Dr. Weston Price, feel that these are things we should be eating because our bodies need them.

2) Correctly prepared glandular substances, as mentioned, provide the body with proteins, growth factors, and other cofactors that the gland needs for repair.

3) Substances like pancreas glandular are also rich in active enzymes and proenzymes that the organ normally provides. Although we think of things like pancreatic enzymes as only playing a role in digestion, research is shedding light on a variety of other functions they may have in the body, including the inhibition of oncogenic processes.[ii]

4) The consumption of small amounts of proteins that glandulars provide may promote immune tolerance, decreasing immune reactions to self-proteins. This is a concept many are familiar with, known as oral tolerance.[iii] A common example of oral tolerance is how the consumption of local honey or bee pollen granules may help reduce the allergic response to the pollen one inhales in the air in the spring. Long ago, our ancestors didn’t have problems of autoimmunity like we do today, and this may be in part because of their regular consumption of glandular substances.

FOCUS: Tell me about how you use glandulars in your practice.

LLI: Many of the patients I see have fatigue syndromes. For these patients, I find adrenal and hypothalamus glandular supplementation to be invaluable. Although many practitioners may think of adrenal glandular in the case of fatigue, hypothalamus is also needed for many patients. Supplementation of hypothalamus glandular can be particularly helpful if a patient presents with depression and/or anxiety in addition to fatigue. I dose hypothalamus glandular once or twice daily, at lunch and bedtime, and find that it also can be very helpful with sleep when taken later in the day. Dr. Gonzalez used to refer to the hypothalamus glandular as “God’s own antidepressant,” and I still use it much like that to this day.

I use adrenal glandulars in different formats: Some provide just the adrenal cortex while others also provide the adrenal medulla. If a patient has fatigue along with salt cravings, I find they do better with the adrenal cortex. If they tend to be a “go-go-go” type that presents with fatigue, particularly fatigue that develops after a long period of being high functioning, I find that an adrenal product that includes the medulla can be more helpful.

The effect of adrenal glandulars is very gentle, and, much like we discussed, provides the building blocks for the body’s own adrenal gland to resume normal function. If someone is very depleted, they may need the adrenal substances up to three times a day, but with time this amount usually decreases. That said, when patients present with overt adrenal insufficiency (or hypothyroidism) I still use medications that are indicated in these situations.

Although some individuals voice concerns that providing someone with adrenal glandular substances for a long period of time may lead to dependency or the development of Cushing’s syndrome, I have never seen this happen despite using them often for multiple years. Rather than seeing a dependency develop, I find that the body is slowly restored and needs less of the adrenal glandular. I had one patient who was on a protocol that included adrenal glandulars for many years. As her body healed, she became aware of when she needed to decrease her therapies. With too much of the adrenal glandular, she would have a bit of a headache, but with too little, her fatigue returned. She found that roughly one capsule a week was enough to keep her function optimal. A mild headache like she experienced is a common sign that the dose of an adrenal glandular should be decreased.

I also use pancreatic glandulars in my practice for a variety of things. Many patients I work with have digestive symptoms due to pancreatic insufficiency, and supplementation with the pancreatic glandulars before meals can be life changing. This was actually how Dr. Kelley also became aware of the pancreatic glandulars—he had an abdominal mass, thought to be pancreatic cancer, which led to severe digestive symptoms, and he found he needed to ingest pancreatic enzymes around the clock to keep his digestive symptoms at bay. I prefer to use pork pancreatic glandulars because the enzymes needed for digestion in the pig, an omnivore, are closer to human enzymes than those of cattle or sheep, which are both ruminants. Lamb is my second choice if an individual can or will not use the pork product.

I find the pancreatic glandular supplementation to be just as effective as the medications many of these patients take. I prefer it over supplementation with digestive enzyme combinations, as the glandulars are the most natural, not requiring any chemical processing.

Dr. Gonzalez and I both preferred the freeze-dried preparation of the pancreatic glandulars as opposed to a more purified extraction of single enzymes. In Dr. Gonzalez’s survey of the hundreds of people Dr. Kelley worked with through the years, he noted that those who experienced the greatest recovery were treated in an era in which Dr. Kelley was using a pancreatic glandular preparation that contained a high percentage of inactive precursors with a modest amount of activated enzymes—not in the later years, when he was using a product that only provided the activated, defatted, pancreatin.[iv]

FOCUS: Besides using adrenal and hypothalamus glandulars for fatigue and pancreatic glandulars for digestive insufficiency, what other glandulars might you use in your practice for some of the common things we all struggle with, like reducing the risk of an infection?

LLI: I often use thymus glandular for this purpose, and I myself take it regularly in winter. For seasonal support I often take it twice daily, but if I feel like I may be on the verge of getting sick, I’ll up the dose to three capsules three times a day. For patients who are frequently getting sick, I’ll put them on thymus glandular at a dose somewhere between these. I also often use liver glandular in my practice, as it is very nutritional. In this day and age, with the busy, stressful nature of our lives, many people—not just those who are dealing with a chronic disease—benefit from adrenal and hypothalamus glandular for support from time to time.


For more reading on the topic of pancreatic glandular therapies, the reader is encouraged to seek out the texts referenced within this interview, as well as the text by Dr. Isaacs and Dr. Gonzalez, The Trophoblast and the Origins of Cancer.

[i] Kelley WD. One Answer to Cancer. Los Angeles, CA: Cancer Book House; 1969.

[ii] Novak JF, Trnka F. Proenzyme therapy of cancer. Anticancer Res. 2005 Mar-Apr;25(2A):1157-77.

[iii] Rezende RM, Weiner H. History and mechanisms of oral tolerance. Semin Immunol. 2017 Apr;30:3-11.

[iv] Gonzalez NJ. The history of the enzyme treatment of cancer. Altern Ther Health Med. 2014 Oct;20 Suppl 2:30-44.

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8 Comments. Leave new

  • Colleen Shetland
    April 15, 2019 6:49 pm

    So how can I find the adrenal glandulars? Is this by prescription only?
    Colleen Shetland

  • Where and how can I gets these?

  • Deirdre Hanvey
    June 25, 2020 5:18 pm

    What is your opinion on ovarian glandular? Is it safe to take them with estrogen? Would they benefit a post-menopausal woman?

    • Leah Jamieson
      April 5, 2023 9:47 am

      Hi Deirdre

      All glandular products have the intention of supporting the health and function of the target tissue. Used as indicated they will be safe to consume with normal prescription oestrogen, but do organise periodic checks with your GP for oestrogen status as they may facilitate some increased oestrogen production and the medication can be altered accordingly.

      Michael Ash

  • Deirdre posed a good question. An answer would be appreciated?

  • I am just learning about glandulars. Could anyone give an opinion on what is the best route for low levels of oestrogen and progesterone? Female, mid 50’s. Would I aim to consume hypothalamus as this seems to control everything or am I looking at this wrongly?
    Many thanks for any opinions?

    • I would first consider Equi-Fem (BRC ), this is a broad-spectrum female multi-vitamins with vitamins, minerals, botanicals and organ/glandular specific support (the glandulars also include the pituitary/hypothalamus and the adrenal complex ). Here is a link to the product –

      You could also consider thyroid glandular support for a woman over 40 and adrenal support (there is adrenal glandular in the equi-fem also)
      . Also, adrenal /stress supporting products will also be supportive and used on a case by case basis.

      Hope this helps,
      Karen Devine R.Nutritionist (MBant), Funtional medicine (AFMCP), R.Naturopath.


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