Glutamine – Effective in resolution of Post Infective IBS
Functional gut problems such as IBS remain a considerable challenge to both clinician and patient. Finding safe and simple interventions as therapeutic strategies is an important part of ongoing research. Many practitioners are familiar with the use of the amino acid L-glutamine as a nutrient that confers benefit to gastro intestinal tracts experiencing increased levels of permeability and translocation of immune activating components such as LPS.
- Published in Abstracts
As functional disorders of the gut continue to increase in occurrence and develop in frequency across all population groups, a broad based review in the Journal Digestive Disorders published in Feb 2018 is a welcome chance to tease out elements of discord and dysbiosis that present opportunities for personalised intervention.[1]
Background and Summary: Traditionally, functional gastrointestinal disorders (FGID), including functional dyspepsia or irritable bowel syndrome (IBS), are defined by more or less specific symptoms and the absence of structural or biochemical abnormalities that cause these symptoms. This concept is now considered to be outdated; if appropriate tests are applied, structural or biochemical abnormalities that explain or cause the symptoms may be found in many patients. Another feature of FGID are the highly prevalent psychiatric comorbidities, such as depression and anxiety.
- Published in Abstracts
Understanding Irritable Bowel Syndrome (IBS) can lead to solutions!
A summary of key points.
In this mini update, learn more about possible contributors to IBS, and how simple diet or supplemental interventions may improve it. There’s a lot more than just probiotics to try!
Learn about:
- The importance of the pancreas and digestive enzyme secretion,
- Support for improving constipation,
- And how mealtime habits can be a simple solution!
- Published in News
Dietary guidance normalises large intestinal endocrine cell densities in patients with irritable bowel syndrome
A research paper in the European Journal Of Clinical Nutrition published a paper looking at the effects of a low POLYOL diet on a subset of endocrine cells linked to IBS in a set of symptomatic patients. The results suggest that the diet has an effect on the cell expression.
Background/Objectives:
To determine the large intestinal endocrine cell types affected following dietary guidance in patients with irritable bowel syndrome (IBS).
- Published in Abstracts
IBS – Is a Low FODMAP Diet Effective?
Unless you have been hiding away from all published materials you will be aware that Monash University in Australia have proposed and others have supported that for people with irritable bowel syndrome, that following a diet low in FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols content will result in symptom resolution.
Yet here at Clinical Education we have stressed that following this diet has risks of key nutrient insufficiencies and in particular those foods rich in aryl hydrocarbon receptor agonists, which are vital for gut mucosal immune balance and competence. In effect the use of a low FODMAP diet for long term health is not justified, but short term intervention may be helpful.
- Published in News
A paper in the American Journal of Gastroenterology looks at various markers to see if it is possible to use them to differentiate between IBS and IBD.[1]
Objectives:
Irritable bowel syndrome (IBS) is viewed as a diagnosis of exclusion by most providers. The aim of our study was to perform a systematic review and meta-analysis to evaluate the utility of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), faecal calprotectin, and faecal lactoferrin to distinguish between patients with IBS and inflammatory bowel disease (IBD) and healthy controls (HCs).
- Published in News
Perilla Targets Inflammation: Joins Traditional Gut Nutrients as Potent Anti-spasmodic and Anti-inflammatory
The remedies for gastrointestinal complaints are legion and stretch back far in human history. Ancient Chinese physicians prescribed anise for flatulence, while Dioscorides, chief physician for the Roman army, recommended garlic for parasites. Many are effective and stand the test of time, but contemporary scientific research on novel extracts offers up surprising new finds. The Asian plant, Perilla (Perilla frutescens) for example, offers valuable assistance in the management of functional gut problems.
- Published in Reviews
Perilla Extract (Benegut®) Improves IBS symptoms
A study published in the BMC Complementary and Alternative Medicine Journal identifies a number of benefits and improved function, achieved in people with IBS ( a functional loss of tolerance in the GI Tract) when consuming a 300mg daily dose of Perilla Extract.[1]
- Published in Abstracts
Conclusions Patients complaining of flatulence have a poor tolerance of intestinal gas, which is associated with instability of the microbial ecosystem.[1]
Significance of this study
What is already known on this subject?
- Some patients specifically complain of excessive evacuation of gas per anus.
- Intestinal gas content depends by-and-large on gas production by bacterial fermentation of unabsorbed substrates.
- Diet influences anal gas evacuation and gut microbial composition.
- A proportion of patients complaining of flatulence have increased number of gas evacuations, but the net volume of gas evacuated is within the normal range.
- Flatulence is associated with abdominal symptoms.
- Published in Abstracts
Faecal Microbiota Transplantation for Inflammatory Bowel Disease
The use of faecal transplantation as a therapeutic tool for not only Clostridium Difficile Infection but as a mechanism for changing the composition of colonic microbiota for the purpose of resolving numerous persistent inflammatory conditions is starting to gain increased interest in the research and medical communities.
Medscape recently published a summary of many of the key areas and I have extracted and edited a small section for peoples review.
- Published in Abstracts
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