Vitamin D and Pregnancy
New research from the American Heart Association reveals a link between vitamin D deficiency at birth and throughout early childhood with elevated systolic blood pressure during later years. Those children with low vitamin D levels through early childhood were found to have double the risk of high blood pressure in adolescence.
- Published in News
The Big Vitamin D Mistake
The prohormone/nutrient vitamin D is well recognised to play numerous roles in the generation and management of human health, and for over a decade papers in their thousands have been published exploring its usefulness. But have they determined an oral dose that is lower than we need? A paper out in the Journal of Preventative Medicine and Public Health suggest we have – that an oral adult dose of 10,000iu is a daily requirement and that blood levels ≥100 nmol/L should be aimed for.[1]
The Abstract says: Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities’ decision to fortify dietary milk products with cholecalciferol. The role of vitamin D in innate and adaptive immunity is critical. A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L.
- Published in News
Does Vitamin D Play a Role in Autoimmune Endocrine Disorders? A Proof of Concept.
Jan 2017 saw the publication of a review article on the potential role of Vitamin D as a risk factor in the development in the generation of autoimmune disorders.[1]
In the last few years, more attention has been given to the “non-calcaemic” effect of vitamin D. Several observational studies and meta-analyses demonstrated an association between circulating levels of vitamin D and outcome of many common diseases, including endocrine diseases, chronic diseases, cancer progression, and autoimmune diseases.
- Published in Abstracts
The recommendation for consumption of calcium over the typically recognised minimum official recommendations in the UK and Nordic countries of 700-800 mg/day of dietary calcium for adults appears to have no substantive benefit on fracture prevention. There is currently little, if any, firm evidence that higher intakes prevent bone loss, falls, or fractures in middle aged and older women and men living in the community.[1],[2]
- Published in News
Vitamin A Recap
“A vitamin is a substance that makes you ill if you don’t eat it.” (Albert Szent-Gyorgyi, Nobel Prize in Physiology or Medicine, 1937).
Vitamins are natural components of foods and are organic compounds distinct from fat, carbohydrates and proteins. Vitamin A is the generic descriptor for compounds with the qualitative biological activity of retinol. Unlike beta-carotene, vitamin A is not an antioxidant and its benefit is related to its intimate relationship with immune reactions.
The effect of vitamin A on immune function is wide-reaching and its deficiency appears to affect immunity in several ways. Both the innate and adaptive immune responses are affected by lack of vitamin A.
- Published in Abstracts
Vit D and IBD
A research paper published in the United European Gastroenterology Journal showed that if you are experiencing a period of remission with Cohn’s disease that Vitamin D confers additional benefit in restoring/maintaining appropriate gut permeability.[1]
In this small study – some 27 people were involved, all of whom were determined to be in remission at the time of the oral supplementation with either 2000 iu of vitamin D or a placebo for 90 days. They found, that patients treated with the supplementation were more likely to maintain their intestinal permeability, whereas this deteriorated in the placebo group. Increased intestinal permeability is considered a measure of gut leakiness, which is shown to predict and precede clinical relapse in CD. In addition, patients with the highest blood levels of vitamin D had signs of reduced inflammation (measured by C-reactive protein and antimicrobial peptides), and these patients also reported better quality of life.
- Published in Reviews
Vitamin D supplements can reduce COPD lung disease flare-ups by over 40% in patients with a vitamin D deficiency – according to new research from Queen Mary University of London. COPD (chronic obstructive pulmonary disease) includes conditions such as chronic bronchitis and emphysema, and is thought to affect more than 3 million people in the UK.
The NIHR-funded randomised trial, published in the journal Lancet Respiratory Medicine, included 240 patients with COPD in and around London. Half of the patients (122) received vitamin D supplements (6 x 2-monthly oral doses of 3mg) and the other half (118) received an equivalent placebo. The risk, severity and duration of flare-ups was then compared between the two groups.[1]
- Published in News
Vitamin A: Friend or Foe
Reading Time: 4 minutes
It is well established that high retinoic acid (RA) levels leads to teratogenic effects both in human and experimental models. Brain abnormalities such as microcephaly, impairment of hindbrain development, mandibular and midfacial underdevelopment, and cleft palate are all implicated.[1],[2] Ingested vitamin A, a fat-soluble vitamin, is delivered to the blood via the lymph system in
- Published in Reviews
Here Comes The Sun – How Vitamin D Relaxes Blood Vessels
It’s not just your mood that the dark months of winter can influence. Low levels of sunlight also mean lower levels of vitamin D in the body. Vitamin D deficiency can trigger a range of diseases but until recently little was known about the exact biological mechanisms behind this. A research team at the University of Veterinary Medicine, Vienna has now decrypted one of these unknown molecular mechanisms. Vitamin D regulates the elasticity of blood vessels and thus also affects blood pressure amplitude. The results were published earlier this year in the journal Molecular Endocrinology.[1]
- Published in News
Older Population Experiences Vit D Deficiency More Commonly – What Are The Risks?
Having severe vitamin D deficiency may put people aged 65 years and older at more than twice the risk of having self-reported respiratory disease, according to an article published online May 6 in the Journal of the American Geriatrics Society.[1] The author Dr Hirani had in 2010 identified a similar pattern in older member of the UK population, and described it as a public health problem.[2]
- Published in Reviews
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