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Comment: Of course, everyone would agree that all persons should be encouraged to eat a good diet, but we are far from achieving this goal, especially among the poor. In most cases, a simple way to improve micronutrient status is to take an MVM. However, even if one eats an ideal diet and takes an

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Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay. Deficiencies in many micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo. Some of these deficiencies also cause mitochondrial decay with oxidant leakage and cellular aging and are associated with late onset diseases such as cancer. I propose DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity.

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Vitamin D insufficiency is common in the United States; the elderly and African-Americans are at particularly high risk of deficiency. This review, written for a broad scientific readership, presents a critical overview of scientific evidence relevant to a possible causal relationship between vitamin D deficiency and adverse cognitive or behavioural effects. Topics discussed are 1)

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As many as one-third of mutations in a gene result in the corresponding enzyme having an increased Michaelis constant, or Km, (decreased binding affinity) for a coenzyme, resulting in a lower rate of reaction. About 50 human genetic dis-eases due to defective enzymes can be remedied or ameliorated by the administration of high doses of the vitamin component of the corresponding coenzyme, which at least partially restores enzymatic activity.

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This review is part of a series intended for non specialists that will summarise evidence relevant to the question of whether causal relations exist between micronutrient deficiencies and brain function. Here, we focus on experiments that used cognitive or behavioural tests as outcome measures in experimental designs that were known to or were likely to result in altered brain concentrations of the n–3 fatty acid docosahexaenoic acid (DHA) during the perinatal period of “brain growth spurt.”

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Folic acid, or vitamin B9, essential for red blood cell health and long known to reduce the risk of spinal birth defects, may also suppress allergic reactions and lessen the severity of allergy and asthma symptoms, according to new research from the Johns Hopkins Children’s Centre. In what is believed to be the first study in humans examining the link between blood levels of folate – the naturally occurring form of folic acid – and allergies, the Hopkins scientists say results add to mounting evidence that folate can help regulate inflammation. Recent studies, including research from Hopkins, have found a link between folate levels and inflammation-mediated diseases, including heart disease. Cautioning that it’s far too soon to recommend folic acid supplements to prevent or treat people with asthma and allergies, the researchers emphasise that more research needs to be done to confirm their results, and to establish safe doses and risks.

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Abstract: The relation between residential magnetic field exposure from power lines and mortality from neurodegenerative conditions was analysed among 4.7 million persons of the Swiss National Cohort (linking mortality and census data), covering the period 2000-2005. Cox proportional hazard models were used to analyse the relation of living in the proximity of 220-380 kV power

Summary: In a cross-sectional study involving 242 healthy young women (Black and White) between the ages of 18 and 21 years, who were followed for 10 years, plasma levels of ascorbic acid (vitamin C) were found to be inversely associated with systolic and diastolic blood pressure. Subjects in the highest fourth of plasma ascorbic acid

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Close, tightly orchestrated interactions between the intestinal epithelium and the mucosa-associated immune system are critical for normal intestinal absorptive and immunological functions. Recent data indicate that commensal intestinal microbiota represents a major modulator of intestinal homeostasis. This review analyses the process of intestinal colonisation and the interaction of microbiota with the intestinal epithelium and mucosal

Abstract: Immunological dysregulation is the cause of many non-infectious human diseases such as autoimmunity, allergy and cancer. The gastrointestinal tract is the primary site of interaction between the host immune system and microorganisms, both symbiotic and pathogenic. In this Review the authors discuss findings indicating that developmental aspects of the adaptive immune system are influenced

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