Mucins – Slimy Viral Defences
It is probably true to state that most of us are not attracted to the idea that mucus is a substance we should really spend any substantive time investigating. But as far as our wet tissues are concerned this is the neighbour they all want on their side. This sticky gloop contributes to mucosal immunity by allowing nutrients and other valuable molecules to pass whilst preventing pathogen adhesion.
A team of MIT researchers have added to our understanding of mucins and their molecular structure through their comprehension of their antiviral activity.
The failure of these mucins may account for some of the inter-individual variation of infection susceptibility, as the mucin production is affected by diet, age and even seasons.
The team discovered that exposing mucins and epithelial cells to a high salt concentration decreased mucin permeability and may account for some of the benefits seen with a salt water gargle.
If this is true, then mucins would be an interesting supplement for hygiene or health products, or lubricants to support the natural immune system. Obtaining large quantities of mucins from human sources such as breast milk is difficult, though. The mucosa of porcine stomachs, from which mucins can be isolated in bulk, could provide an attractive alternative source for mucin glycoproteins. Indeed, porcine gastric mucins have previously been used as a component of artificial saliva for the treatment of subjects suffering from salivary insufficiency (xerostomia).
 Lieleg O, Lieleg C, Bloom J, Buck CB, Ribbeck K. Mucin biopolymers as broad-spectrum antiviral agents. Biomacromolecules. 2012 Apr 4. View Abstract View Full Paper
Thursday 19th November 2015
This evening seminar will take the gathering understanding of the role of our mitochondria as sentinels of metabolic and immune dysfunction and how lifestyle including food and food concentrates are able to either increase or decrease their viability. As our understanding of the molecular influence of food continues to grow, significant understandings become all the more important in our delivery of advice and recommendations. You may think that this subject is too esoteric or removed from every day clinical life, but never has an area of application been more relevant to almost all the clients or people that you support. Delivered in an easy to appreciate format with clinical applicability, we feel confident that this will enhance your confidence and improve your outcomes. We will be recording the event for people attending and those unable to travel..Click for further information
- Dr Carrie Decker ND explores the role of a numb...
- Across the world there are chronic diseases aff...
- The recommendation for consumption of calcium o...
- As a delegate of the Functional Nutrition Cours...
- Dr Carrie Decker ND, explores the mechanisms be...
Updates on your email
Don't miss out on our email updates