Gut Immune Defect Links Bacteria and Metabolic Syndrome
The connection between gut bacteria and obesity has gained some weight, with new findings demonstrating links in mice among immune-system malfunction, bacterial imbalance and increased appetite.
Mice with altered immune systems developed metabolic disorders and were prone to overeating. When microbes from their stomachs were transplanted into other mice, they also become obese. These latest findings add weight to the growing appreciation about the role of the bacteria in and on our bodies. We are all outnumbered in terms of human versus bacterial cells and the concept of human and bacteria symbiosis as a super-organism is gaining traction.
Already there have been strong associations between asthma, some cancers, autoimmune conditions and unwanted weight gain.
Gut flora have also been linked to obesity. In 2006, researchers led by Washington University microbiologist Jeffrey Gordon documented bacterial changes in the stomachs of mice who became obese on high-fat diets. Michael Ash wrote a review article in CAM magazine on this subject back in 2005 and it can be read in our review section.
This paper discusses a serendipitous discovery concerning metabolic syndrome, a western world problem leading to hyperglycaemia, hyperlidemia, insulin resistance, obesity and liver steatosis.
This is thought mainly due to dietary changes and reduction in exercise that in turn contributes to inflammation and loss of insulin sensitivity. This paper explores the role that gut bacteria may have in contributing to this, in particular the firmicutes and bacteroidites.
Our results suggest that the specific composition of microbiota to which individuals are first exposed may be an important means by which early environment exerts a lasting influence on metabolic phenotype. They also suggest that the excess caloric consumption driving the current epidemic of metabolic syndrome may be caused, at least in part, by alterations in host-microbiota interactions.
The gut microbiota is shaped by both environment and host genetics with the innate immune system in particular, long-appreciated for its role in defending against infection by pathogenic microbes, now suggested to play a key role in regulating the gut microbiota. Thus, in addition to its role in infection/inflammation, innate immunity may play a key role in promoting metabolic health. One of the mucosal immune proteins that seems to be developing an important role in this balance is SIgA.
An explanation for some of the changes in gut microbiota is founded in the hygiene theory, and the almost ubiquitous presence of antibiotics both as prescribed medication and present in the environment may be partly to blame. We know that a single course is able to disrupt bacterial colonies for up to 6 months. It may be a secondary effect of antibiotic use, that metabolic syndrome and obesity are developing in medicalised countries.
There may also be relevance in terms of the introductory bacteria that each human is exposed to from in utero, and ex utero experiences. If the mothers bacteria are supporting her obesity, then the transfer of this microbial species may also contribute to difficulty in managing weight in the child through to adult hood.
 Matam Vijay-Kumar, Jesse D. Aitken, Frederic A. Carvalho, Tyler C. Cullender, Simon Mwangi, Shanthi Srinivasan, Shanthi V. Sitaraman, Rob Knight, Ruth E. Ley, Andrew T. Gewirtz. Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor-5Science, Vol. 327, No. 5970, March 4, 2010. View Abstract
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Thursday 19th November 2015
This evening seminar will take the gathering understanding of the role of our mitochondria as sentinels of metabolic and immune dysfunction and how lifestyle including food and food concentrates are able to either increase or decrease their viability. As our understanding of the molecular influence of food continues to grow, significant understandings become all the more important in our delivery of advice and recommendations. You may think that this subject is too esoteric or removed from every day clinical life, but never has an area of application been more relevant to almost all the clients or people that you support. Delivered in an easy to appreciate format with clinical applicability, we feel confident that this will enhance your confidence and improve your outcomes. We will be recording the event for people attending and those unable to travel..Click for further information
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