Selenium, ’Shrooms, Astragalus, and Andrographis
How a Trace Mineral, Maitake Mushroom, and Adaptogenic Herbs Offer Comprehensive Immune Protection by Carrie Decker ND.
The times when we need additional immune support often hit us by surprise. Whether it is waking up with a sore throat and the sniffles or leaving work early with a fever and the chills, we often don’t see illness coming until it is upon us full bore. In retrospect, we may associate an illness with the coughing passenger on a recent flight, the kids being back at school, or the sick patients coming in and out of the office. The body’s immune system is also challenged by stress and/or sleepless nights, with cortisol impacting it as well.
Even worse than acute infections, a diagnosis of cancer hits many unsuspecting people entirely out of the blue. One might associate it with various circumstances that increase the risk of oncogenic cellular changes, such as genetics, toxicant exposure, or infections. However, many individuals are subject to this same set of conditions but do not develop malignancy. We must therefore question if the body’s immune system could better protect us from the cellular mutations that eventually expand into cancer.
Thankfully, several natural agents have shown promise in supporting our immune defenses, protecting us from both acute, self-limited illnesses and malignancy.
The Detoxifying and Immune Effects of Selenium
The trace mineral selenium is critical for the production and function of several selenoproteins. These selenoproteins, in addition to those required for thyroid hormone metabolism, include five glutathione peroxidase enzymes that serve to reduce pro-oxidants like hydrogen peroxide, lipohydroperoxide, and peroxynitrite by coupling them with glutathione, which serves as a reducing agent., Other selenoproteins known as thioredoxin reductases and methionine sulfoxide reductase B1 also help reduce reactive oxygen species and regenerate other antioxidants., Collectively, they protect our cell membranes and DNA from damage,, help the body detoxify and neutralize the oxidants generated from harmful substances (such as mercury), and support cellular energy production and communication.
Although one might not think of antioxidant protection and healthy immune system function as going hand in hand, they do. It has been demonstrated that blood levels of selenium are associated with levels of glutathione in the human body, and supplementation with selenium significantly increases glutathione levels in humans. Depletion of glutathione is associated with impaired immune function,, while an increase in glutathione has been shown to parallel improved immune function.
Beyond glutathione, there are many direct mechanisms via which selenium has been shown to affect immune system function. In vivo, selenium supplementation has been shown to increase natural killer (NK) cell activity (humans),, neutrophil migration, T cell proliferation and response, and vaccine-induced immunity (humans). Selenium deficiency is associated with more severe illness caused by viral pathogens,. In patients with HIV, selenium deficiency is an independent predictor of HIV-1 mortality, while studies support the use of selenium to reduce the HIV-1 viral burden and improve CD4 cell counts.
Considering selenium’s importance for the body’s antioxidant systems, it isn’t surprising that the mineral also helps protect the body against cellular changes associated with cancer. Lower levels of selenium intake are associated with an increased risk of certain types of cancer,,, while supplementation with selenium has been shown to decrease DNA damage in humans and induce cellular apoptosis in cells afflicted with cancer-causing mutations. Selenium supplementation has additionally been shown to improve white blood cell counts and reduce the side effects associated with certain types of chemotherapy, and radiation treatment.
Dietary supplementation with selenium at a level of 200 mcg is generally considered safe, while the Food and Nutrition Board of the US Institute of Medicine set the tolerable upper intake level at 400 mcg per day.
The Immune and Antioxidant Effects of Maitake
Many are familiar with the medicinal benefits of certain types of mushrooms—maitake (Grifola frondosa), turkey tail (Coriolus versicolor), and reishi (Ganoderma lucidum) are just a few of those well known for their immune system–supportive effects. Many of these medicinal mushrooms are considered immunomodulators, and are taken on a daily basis as tonics to enhance the innate protective response of the immune system. What many do not consider, however, is how the selected mushroom parts, or the growth media, may enhance the benefits of these fungi.
The primary active constituents from medicinal mushrooms are polysaccharides known as beta glucans, which interact with the body’s immune system receptors, activating the complement system and enhancing the function of macrophages and NK cells. The concentration of these beta glucans and other nutritional components vary widely among mushroom species and structural features, and are even influenced by culture (growth) media., Although total polysaccharides occur at high levels in the mycelium, the fruiting body (stem, cap, and gills) and spores have greater antioxidant potential. Thus, the diverse array of potential benefits from mushroom products can be best experienced with products utilizing the fruiting body, alone or in combination with the mycelium, rather than the mycelium portion alone.
Water and alcohol extracts of maitake fruiting bodies have been shown to have a high free radical scavenging potential and beta glucan content,, enabling them to deliver both antioxidant protection and innate immunity-enhancing effects., Studies show extracts from maitake enhance NK cell activity,. The immune defense–enhancing effects of maitake, and maitake in combination with shiitake, were shown to be even more potent than those of a commonly used shiitake and basidiomycetes mushroom preparation. A substantial array of research in animal models show these mechanisms of action translate to cancer-prevention benefits.
Human studies also show extracts from maitake have a significant effect on immune system function. In female, postmenopausal breast cancer survivors, supplementation with maitake was shown to variably affect immune system function, with optimal dosing ranging from 5 to 10 mg/kg daily (depending on the desired effect). However, in this short, three-week period, no clinical efficacy endpoint was evaluated. In cancer patients not taking anticancer drugs, maitake extract was shown to increase NK cell activity, reduce the expression of tumor markers, and hinder metastatic processes. When added to chemotherapy, maitake enhanced immune cell activity and showed benefits in individuals with liver, lung, and breast tumors. Finally, patients with myelodysplastic syndrome (a syndrome of ineffective erythropoiesis associated with bone marrow dysfunction) who received 3 mg/kg of maitake extract twice daily were shown to have enhanced neutrophil and monocyte function.
The Immune-Strengthening Effects of Astragalus
Astragalus is one of the 50 fundamental herbs used in traditional Chinese medicine, considered a “toner of spleen qi.” Much of the research in both Chinese and Western medicine pertaining to astragalus is related to its effects on immune system function,, including those related to cancer protection., Astragalus is also used in Chinese medicine for many cardiac issues, with positive clinical findings in congestive heart failure (CHF), ischemic heart disease, and settings of heart surgery.
Although Astragalus membranaceus is the species of this family that has been most highly researched for its medicinal benefits, over 46 types of astragalus have been studied in recent years, being shown to be highly uniform in their composition of active constituents.59 Studies have shown that astragalus stimulates immune system function, reduces inflammation, and has antioxidant effects—mechanisms which translate to its liver-, cardiac-, and cancer-protective effects. Studies have shown astragalus (or its active constituents) improve macrophage and neutrophil phagocytosis, seen in chronic viral (humans) or asthmatic settings.,
In patients with CHF, treatment with astragalus has been shown to significantly increase CD4 levels and CD4/CD8 ratio, a parameter which not only reflects the strength of immune system response in those with HIV, but also may be associated with mortality in other settings., In patients experiencing acute exacerbations of chronic obstructive pulmonary disease (COPD), treatment with 15 mg of astragalus twice daily for 14 days, in conjunction with traditional clinical therapy (antispasmodic, expectorant, anti-asthmatic, and anti-infection treatments as indicated), was shown to significantly improve parameters of immune system function (CD4/CD8 ratio and NK cell levels) and decrease cytokines associated with inflammation (TNF-α, IL-8, and IL-1β) compared to the group not receiving astragalus.
The King of Bitters, Andrographis
Andrographis (Andrographis paniculata) is a plant native to South and Southeast Asia that is revered in many medical traditions, including Ayurveda and Chinese medicine. It has many common names that convey its potential therapeutic properties, ranging from “King of Bitters” to “Indian Echinacea.” Considered a botanical with adaptogenic properties, it has also been shown to modulate the response to stress. Beyond these things, it has clinical evidence of reducing triglycerides, and anti-diabetic effects have also been seen in animal studies.
The most well-known effects of andrographis, however, are with respect to the immune system. In vitro and animal studies have shown andrographis stimulates the nonspecific and antigen-specific immune response, enhances NK cell activity and complement-mediated cytotoxicity, and increases cytotoxic lymphocyte production and their response. Yet it also has anti-inflammatory effects, having been shown to reduce levels of cytokines and chemokines associated with lipopolysaccharide (LPS)-induced immune system activation., Antioxidant effects have also been seen in multiple studies, possibly mediated by nuclear factor erythroid 2-related factor (Nrf2) activation.,
Human studies have also shown an increase in immune system activity with andrographis, both acutely and with longer-term supplementation. Acute supplementation with a crude andrographis powder at a dose of 4.2 g daily for three days was shown to increase white blood cells and absolute neutrophil counts in healthy volunteers. In patients with HIV, andrographis was shown at a dosage of 10 mg/kg daily to significantly increase mean CD4 lymphocyte levels from a baseline of 405 cells/mm3 to 501 cells/mm3 after three weeks.
Therapeutically, andrographis has been clinically studied in settings of acute upper respiratory infections (URIs) and the common cold. In a randomized, double-blind, placebo-controlled trial (RDBPCT), adult patients with the common cold received 1,200 mg of andrographis extract or placebo daily for five days. Evaluation of symptoms occurred at baseline, day two, and day four with a self-assessment questionnaire. At day two, significant decreases in intensity of tiredness, sleeplessness, sore throat, and nasal secretions were observed in the andrographis group as compared to placebo. At day four, significant decreases in all symptoms—which additionally included headache, earache, phlegm, and frequency and intensity of cough—were seen in the andrographis group, with no adverse effects being reported.
An improvement in the symptoms of and recovery from uncomplicated URIs has also been seen in RDBPCTs with short-term use of standardized andrographis extracts. A systemic review of seven RDBPCTs investigating the use of andrographis for the treatment of URIs suggested andrographis had a superior effect to placebo in relieving the subjective symptoms of uncomplicated URIs as well as possible preventative effect. Adverse effects were limited, being mild and infrequent.
As an immune system–modulating adaptogen, andrographis has also been studied in settings of autoimmune disease. In a 12-month study in patients with relapsing-remitting multiple sclerosis (RRMS) who were also being treated with interferon, treatment with 170 mg of andrographis extract twice daily was shown to significantly reduce Fatigue Severity Scores compared to placebo, with a 44% reduction at 12 months. In an animal model of experimental autoimmune encephalomyelitis, andrographis was shown to reduce T cell activation and antibody response to myelin antigens. Additionally, in patients with active rheumatoid arthritis (managed on stable doses of prednisone, chloroquine, and/or methotrexate), 100 mg of andrographis (containing 30% andrographolides) taken three times a day for 14 weeks was shown to significantly decrease the number of swollen joints, total grade of swollen joints, number of tender joints, and total grade of tender joints. In conjunction with the improvements in symptoms, a reduction in rheumatoid factor level was also seen.
Although we often reflect that hindsight is 20/20, there are many times in life when we are able to sense the stress on our immune system prior to the development of a full-blown infectious illness or other immune system challenge. In these instances, support from substances such as the ones detailed in this article may help to mitigate or prevent the untoward changes to our healthy state.
 Karin M, et al. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006 Feb 24;124(4):823-35.
 de Visser KE, et al. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer. 2006 Jan;6(1):24-37.
 Arthur JR, et al. Selenium deficiency, thyroid hormone metabolism, and thyroid hormone deiodinases. Am J Clin Nutr. 1993 Feb;57(2 Suppl):236S-9S.
 Rotruck JT, et al. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973 Feb 9;179(4073):588-90.
 Sies H, et al. Protection against peroxynitrite by selenoproteins. Z Naturforsch C. 1998 Mar-Apr;53(3-4):228-32.
 Arnér ES. Focus on mammalian thioredoxin reductases–important selenoproteins with versatile functions. Biochim Biophys Acta. 2009 Jun;1790(6):495-526.
 Moskovitz J, et al. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12920-5.
 Ursini F, Bindoli A. The role of selenium peroxidases in the protection against oxidative damage of membranes. Chem Phys Lipids. 1987 Jul-Sep;44(2-4):255-76.
 Bera S, et al. Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention? Mutagenesis. 2013 Mar;28(2):127-34.
 Spiller HA. Rethinking mercury: the role of selenium in the pathophysiology of mercury toxicity. Clin Toxicol (Phila). 2018 May;56(5):313-26.
 Papp LV, et al. From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal. 2007 Jul;9(7):775-806.
 Richie JP Jr, et al. Association of selenium status and blood glutathione concentrations in blacks and whites. Nutr Cancer. 2011;63(3):367-75.
 El-Bayoumy K, et al. Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study. Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1459-65.
 Robinson MK, et al. Glutathione depletion in rats impairs T-cell and macrophage immune function. Arch Surg. 1993 Jan;128(1):29-34.
 Look MP, et al. Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection. Eur J Clin Nutr. 1997 Apr;51(4):266-72.
 Arranz L, et al. The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women. Free Radic Biol Med. 2008 Nov 1;45(9):1252-62.
 Kiremidjian-Schumacher L, et al. Supplementation with selenium augments the functions of natural killer and lymphokine-activated killer cells. Biol Trace Elem Res. 1996 Jun;52(3):227-39.
 Dimitrov NV, et al. Modulation of natural killer cell activity by selenium in humans. J Nutr Growth Cancer. 1986.
 McKenzie RC, et al. Selenium: an essential element for immune function. Immunol Today. 1998 Aug;19(8):342-5.
 Broome CS, et al. An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. Am J Clin Nutr. 2004 Jul;80(1):154-62.
 Beck MA, et al. Selenium deficiency increases the pathology of an influenza virus infection. FASEB J. 2001 Jun;15(8):1481-3.
 Beck MA, et al. Selenium deficiency and viral infection. J Nutr. 2003 May;133(5 Suppl 1):1463S-7S.
 Yu SY, et al. Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Biol Trace Elem Res. 1997 Jan;56(1):117-24.
 Baum MK, et al. High risk of HIV-related mortality is associated with selenium deficiency. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Aug 15;15(5):370-4.
 Hurwitz BE, et al. Suppression of human immunodeficiency virus type 1 viral load with selenium supplementation: a randomized controlled trial. Arch Intern Med. 2007 Jan 22;167(2):148-54.
 Hatfield DL, et al. Selenium and selenocysteine: roles in cancer, health, and development. Trends Biochem Sci. 2014 Mar;39(3):112-20.
 Hughes DJ, et al. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. Int J Cancer. 2015 Mar 1;136(5):1149-61.
 Terry PD, et al. Supplemental selenium may decrease ovarian cancer risk in African-American women. J Nutr. 2017 Apr;147(4):621-7.
 Cai X, et al. Selenium exposure and cancer risk: an updated meta-analysis and meta-regression. Sci Rep. 2016 Jan 20;6:19213.
 Cominetti C, et al. Associations between glutathione peroxidase-1 Pro198Leu polymorphism, selenium status, and DNA damage levels in obese women after consumption of Brazil nuts. Nutrition. 2011 Sep;27(9):891-6.
 Sinha R, El-Bayoumy K. Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds. Curr Cancer Drug Targets. 2004 Feb;4(1):13-28.
 Sieja K, Talerczyk M. Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy. Gynecol Oncol. 2004 May;93(2):320-7.
 Hu YJ, et al. The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients. Biol Trace Elem Res. 1997 Mar;56(3):331-41.
 Muecke R, et al. Selenium in radiation oncology-15 years of experiences in Germany. Nutrients. 2018 Apr 13;10(4).
 Schrauzer GN, et al. Nutritional selenium supplements: product types, quality, and safety. J Am Coll Nutr. 2001 Feb;20(1):1-4.
 Food and Nutrition Board, Institute of Medicine. Selenium. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, D.C.: National Academy Press; 2000:284-324.
 Xu Z, et al. Ganoderma lucidum polysaccharides: immunomodulation and potential anti-tumor activities. Am J Chin Med. 2011;39(1):15-27.
 Svagelj M, et al. Immunomodulating activities of cultivated maitake medicinal mushroom Grifola frondosa (Dicks.: Fr.) S.F. Gray (higher Basidiomycetes) on peripheral blood mononuclear cells. Int J Med Mushrooms. 2012;14(4):377-83.
 Schepetkin IA, Quinn MT. Botanical polysaccharides: macrophage immunomodulation and therapeutic potential. Int Immunopharmacol. 2006 Mar;6(3):317-33.
 Akramienė D, et al. Effects of ß-glucans on the immune system. Medicina. 2007 Aug 11;43(8):597.
 Manzi P, Pizzoferrato L. Beta-glucans in edible mushrooms. Food Chem. 2000 Feb 15;68(3):315-8.
 Chattopadhyay S, et al. Bioprocess considerations for production of secondary metabolites by plant cell suspension cultures. Biotech Bioprocess Eng. 2002 Jun 1;7(3):138.
 Heleno SA, et al. Fruiting body, spores and in vitro produced mycelium of Ganoderma lucidum from Northeast Portugal: A comparative study of the antioxidant potential of phenolic and polysaccharidic extracts. Food Res Int. 2012;46(1):135-40.
 Shin YJ, Lee SC. Antioxidant activity and β-glucan contents of hydrothermal extracts from maitake (Grifola frondosa). Food Sci Biotech. 2014 Feb 1;23(1):277-82.
 Yeh JY, et al. Antioxidant properties and antioxidant compounds of various extracts from the edible basidiomycete Grifola frondosa (Maitake). Molecules. 2011 Apr 15;16(4):3197-211.
 Hong L, et al. Antioxidant and immunomodulatory effects of a α-glucan from fruit body of maitake (Grifola frondosa). Food Ag Immunol. 2013 Dec 1;24(4):409-18.
 Kodama N, et al. Stimulation of the natural immune system in normal mice by polysaccharide from maitake mushroom. Mycoscience. 2003 Jun 1;44(3):257-61.
 Adachi K, et al. Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake). Chem Pharm Bull (Tokyo). 1987 Jan;35(1):262-70.
 Haabeth OA, et al. Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells. Oncoimmunology. 2015 Jul 25;5(1):e1039763.
 Wang L, et al. Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice. J Pharm Pharmacol. 2008 Feb;60(2):237-43.
 Inoue A, et al. Effect of maitake (Grifola frondosa) D-fraction on the control of the T lymph node Th-1/Th-2 proportion. Biolog Pharm Bulletin. 2002;25(4):536-40.
 Lei H, et al. MT-α-glucan from the fruit body of the maitake medicinal mushroom Grifola frondosa (higher Basidiomyetes) shows protective effects for hypoglycemic pancreatic β-cells. Int J Med Mushrooms. 2013;15(4):373-81.
 Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb;2(2):14.
 Mayell M. Maitake extracts and their therapeutic potential-a review. Alt Med Rev. 2001 Nov;6(1):48-60.
 Deng G, et al. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol. 2009 Sep;135(9):1215-21.
 Kodama N, et al. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients. J Med Food. 2003 Winter;6(4):371-7.
 Kodama N, et al. Can maitake MD-fraction aid cancer patients? Altern Med Rev. 2002 Jun;7(3):236-9.
 Wesa KM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother. 2015 Feb;64(2):237-47.
 Li X, et al. A review of recent research progress on the astragalus genus. Molecules. 2014 Nov 17;19(11):18850-80.
 Qi Y, et al. Anti-Inflammatory and immunostimulatory activities of astragalosides. Am J Chin Med. 2017;45(6):1157-67.
 Miraj S, Kiani S. Astragalus membranaceus: a review study of its anti-carcinoma activities. Der Pharmacia Lettre. 2016;8(6):59-65.
 Auyeung KK, et al. Astragalus membranaceus: a review of its protection against inflammation and gastrointestinal cancers. Am J Chin Med. 2016;44(1):1-22.
 Zhou ZL, et al. [Study on effect of Astragalus injection in treating congestive heart failure]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Oct;21(10):747-9.
 Li SQ, et al. [Clinical observation on the treatment of ischemic heart disease with Astragalus membranaceus]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Feb;15(2):77-80.
 Wang F, et al. [Effect of Astragalus on cytokines in patients undergoing heart valve replacement]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jun;28(6):495-8.
 Allam RM, et al. Hepatoprotective effects of Astragalus kahiricus root extract against ethanol-induced liver apoptosis in rats. Chin J Nat Med. 2013 Jul;11(4):354-61.
 Ma X, et al. Extracts from Astragalus membranaceus limit myocardial cell death and improve cardiac function in a rat model of myocardial ischemia. J Ethnopharmacol. 2013 Oct 7;149(3):720-8.
 Li W, et al. Detection and evaluation of anti-cancer efficiency of Astragalus polysaccharide via a tissue engineered tumor model. Macromol Biosci. 2018 Sep 6:e1800223.
 Xu HD, et al. Effects of Astragalus polysaccharides and astragalosides on the phagocytosis of Mycobacterium tuberculosis by macrophages. J Int Med Res. 2007 Jan;35(1):84-90.
 Yin G, et al. Effect of two Chinese herbs (Astragalus radix and Scutellaria radix) on non-specific immune response of tilapia, Oreochromis niloticus. Aquaculture. 2006 Mar 31;253(1-4):39-47.
 Sun Y, Yang J. [Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type 1]. Di Yi Jun Yi Da Xue Xue Bao. 2004 Jan;24(1):57-8.
 Wang MS, et al. Clinical study on effect of Astragalus Injection and its immuno-regulation action in treating chronic aplastic anemia. Chin J Integr Med. 2007 Jun;13(2):98-102.
 Mao SP, et al. [Modulatory effect of Astragalus membranaceus on Th1/Th2 cytokine in patients with herpes simplex keratitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Feb;24(2):121-3.
 Ling H, Zhao X. The research progress of mechanism of Astragalus polysaccharides treatment of asthma and prospects. J Zhejiang Chinese Med Univ. 2016 Jan 1(1):72-4.
 Olsson J, et al. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev. 2000 Dec 20;121(1-3):187-201.
 Strindhall J, et al. The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study. Age (Dordr). 2013 Jun;35(3):985-91.
 Jiang D, et al. Milkvetch root improves immune function in patients with acute exacerbation of COPD. Biomed Mater Eng. 2015;26 Suppl 1:S2113-21.
 Kumar A, et al. A review on king of bitter (Kalmegh). Int J Res Pharm Chem. 2012;2(1):116-24.
 Strong KM. “Indian” Echinacea. J Herb Pharmacother. 2003 Jan 1;3(1):115-20.
 Thakur AK, et al. Adaptogenic potential of andrographolide: An active principle of the king of bitters (Andrographis paniculata). J Tradit Complement Med. 2014 Dec 19;5(1):42-50.
 Phunikhom K, et al. Effect of Andrographis paniculata extract on triglyceride levels of the patients with hypertriglyceridemia: a randomized controlled trial. J Med Assoc Thai. 2015 Jul;98 Suppl 6:S41-7.
 Zhang XF, Tan BK. Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats. Acta Pharmacol Sin. 2000 Dec;21(12):1157-64.
 Puri A, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod. 1993 Jul;56(7):995-9.
 Sheeja K, Kuttan G. Modulation of natural killer cell activity, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice. Integr Cancer Ther. 2007 Mar;6(1):66-73.
 Sheeja K, Kuttan G. Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide. Immunopharmacol Immunotoxicol. 2007;29(1):81-93.
 Wong SY, et al. Andrographolide attenuates LPS-stimulated up-regulation of CC and CXC motif chemokines in rodent cortex and primary astrocytes. J Neuroinflam. 2016 Dec;13(1):34.
 Li Y, et al. Andrographolide Inhibits Inflammatory Cytokines Secretion in LPS-Stimulated RAW264.7 Cells through Suppression of NF-κB/MAPK Signaling Pathway. Evid Based Complement Alternat Med. 2017;2017:8248142.
 Pan CW, et al. Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway. Oncotarget. 2017 Jun 20;8(25):41202-10.
 Seo JY, et al. Andrographolide activates Keap1/Nrf2/ARE/HO-1 pathway in HT22 cells and suppresses microglial activation by Aβ42 through Nrf2-related inflammatory response. Mediators Inflamm. 2017;2017:5906189.
 Suriyo T, et al. Clinical parameters following multiple oral dose administration of a standardized andrographis paniculata capsule in healthy Thai subjects. Planta Med. 2017 Jun;83(9):778-89.
 Calabrese C, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res. 2000 Aug;14(5):333-8.
 Cáceres DD, et al. Use of visual analogue scale measurements (VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. Phytomedicine. 1999 Oct;6(4):217-23.
 Saxena RC, et al. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine. 2010 Mar;17(3-4):178-85.
 Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med. 2004 Apr;70(4):293-8.
 Bertoglio JC, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016 May 23;16:77.
 Iruretagoyena MI, et al. Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse. J Pharmacol Exp Ther. 2005 Jan;312(1):366-72.
 Burgos RA, et al. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol. 2009 Aug;28(8):931-46.
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