Impaired Gastric Acidification Negatively Affects Calcium Homeostasis and Bone Mass

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Calcium deficiency in the elderly is associated with low gastric acid secretion and bone loss. A new study linking defects in gastric acid secretion with bone destruction and impaired mineralization bolsters the view that calcium supplements can prevent these bone defects-but do they all work. This paper suggests that altered acidification of the stomach and specific gene deficiencies will dictate the form of calcium supplementation most suitable for the reduction and resolution of osteoporosis.

Schinke T, et al. Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nature Medicine 15, 674 – 681 (2009)
Published online: 17 May 2009 | doi:10.1038/nm.1963 View Abstract

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