Phosphatidylcholine (PC) Controls Inflammation in Ulcerative Colitis

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Phosphatidylcholine (PC) is a major lipid of the gastrointestinal mucus  layer. We  recently showed  that mucus from patients suffering  from ulcerative colitis  has low levels of PC. Clinical studies reveal that the therapeutic addition of PC to the  colonic mucus using slow release preparations is beneficial.

Results:PC induces a prolonged inhibition of TNF-α-induced pro-inflammatory  signalling.  This  inhibition may  be  caused  by  a  shift  of  the  TNF-α  receptors  at  the  surface  to  lipid  rafts. Our  results may offer a potential molecular explanation  for  the  positive role of PC seen in clinical studies for the treatment of ulcerative colitis.

Treede, I Braun, A et al. TNF-alpha induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells. BMC Gastroenterology 2009, 9:53 (13 July 2009) View Abstract View Full Paper

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  • This is an informative study, thank you. The results prove an additional benefit of taking PC supplements in addition to supporting the memory and revitalizing motor skills. It is most likely a supplement that the majority of us should take, especially as we age.


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