Liquid gold. Golden milk. That brilliant saffron-hued spice. We hear a lot about turmeric these days—also known as Curcuma longa—a member of the ginger family, and native of Southeast Asia.[i] Valued for its brilliant hue and distinctive spicy-bitter flavor, its use as a dye, a spice, and in religious ceremonies dates back nearly 4000 years.[ii],[iii] Turmeric is a mainstay in Ayurvedic and Chinese medicine, thanks in large part to curcuminoids—three bright golden-colored, lipophilic polyphenols (curcumin, demethoxycurcumin and bisdemethoxycurcumin), collectively known as “curcumin” that are derived from the plant’s rhizomes.[iv],[v] The main component of the root is a volatile oil containing turmerone.
- Published in Reviews
Transcriptional Regulation of Inflammatory Pain and Hyperalgesia: NF-kB as a Lynchpin and Master Regulator.
The milieu and array of inflammatory cells and inflammatory mediators are crucially involved in the genesis, persistence and severity of pain following trauma, infection or nerve injury . The mechanisms and pathways mediating pain and nociception (hyperalgesia) are transcriptionally regulated. The transcriptional mediator nuclear factor (NF)-κB plays a major role in regulating inflammatory responses, ostensibly via the control of gene expression/suppression. An association has recently emerged to establish a possible link between NF-kB and pain/nociception, purportedly through the regulation of the inflammatory loop and the secretion (biosynthesis) of pro-inflammatory mediators.
- Published in Abstracts
Recent findings suggest that the amino acid glutamine reduces Helicobacter pylori-associated pathology in mice and may therefore have similar effects in humans with gastric ulcers caused by H. pylori.
- Published in Abstracts
18th May 2019
LOBE Medical and Clinical Education are proud to present Lifestyle Medicine Education Course for General Practice. This one-day masterclass will provide busy GPs, Practice Nurses and Pharmacists with tools to tackle complex presentations with simple yet effective evidence derived lifestyle medicine interventions. The increase in non-communicable disease and the rise in lifestyle related illnesses require a broad approach but with specific interventions.Click for further information
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