Reading Time: 7 minutes

histamine_intoleranceDr Carrie Decker ND, explores the mechanisms behind the increasingly recognised and better understood intolerance to histamine (1% of population are likely to suffer). Responsible for a wide range of apparently unconnected symptoms, the ingestion of histamine containing foods by someone ill equipped to adequately render the amine neutralised can result in an unpleasant series of functional problems.

Reading Time: 3 minutes

journalFor some years the notion that adverse responses to environmental triggers may be increasing due to a change in the ongoing exposure to mild immune activating bacteria has been gaining credibility. From Strachans first proposals to now there has been a continuous evolution of the hygiene hypothesis.[1],[2]

  • Hygiene hypothesis – criticised as being too vague, including by Professor Strachan himself
  • Microbial hypothesis (avoiding an overemphasis on cleanliness) and the
  • Old friends hypothesis (implying that microbes that were beneficial for immune system development have been eliminated or replaced).
  • Biodiversity hypothesis expands the hygiene hypothesis to the living environment in general,
  • Biome depletion model views the hygiene hypothesis as an evolutionary mismatch that works in tandem with other mismatches, such as inflammatory diets or vitamin A, D or K deficiency, which undermine immune function in westernised societies.
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A New Form of Food Reactivity

Wednesday, 10 April 2013 by | Comments: 1
Reading Time: 2 minutes

Food Protein Enterocolitis (FPIES) may be a new term to you, but as with a number of emerging subsets of food reactivity it appears to be a little over half as common as IgE food responses (0.34% by 1 year of age; immunoglobulin E-mediated cow’s milk allergy was 0.5%.). So whilst you may not see a case directly in practice, understanding its process and symptoms as well as treatments will prepare you for those cases that seem to fail to respond to normal approaches.

Food Protein Induced Enterocolitis Syndrome (FPIES) is an allergic reaction in the gastrointestinal system. The most common triggers are milk and soy, but any food (even those thought to be hypoallergenic e.g. rice, oat) can cause an FPIES reaction. FPIES typically starts within the first year of life.[1]

Reading Time: 2 minutes

Long implicated in numerous adverse events linked to intestinal immunity and associated mucosal tolerance a recent presentation at the American Academy of Allergy Asthma &Immunology annual meeting has shown a credible causation link between antibiotics and allergy.[1]

In their retrospective case–control study, presented as a late-breaking abstract at the meeting, Dr. Love and colleagues found an almost 2-fold increase in food allergy in children exposed to 3 or more courses of antibiotics between the ages of 7 and 12 months.

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Reading Time: 6 minutes

The LEAP Project

Many Nutritional Therapists will consult people with a well-defined allergy or in some cases a range of symptoms that reflect an allergic response that do not meet the recognised IgE diagnosis. Some of these people will also be experiencing what is known as the ‘allergic march’ – the development of secondary allergenic profiles such as asthma after already having an established food allergy, such as peanut or shellfish.

Asthma Management

Monday, 22 August 2011 by
Reading Time: 2 minutes

The incidence of asthma and allergy are on the rise with ever increasing understanding of the role of unique genetic changes to epithelial tissues and environmental impacts including nutrition and bacteria.[1]

But aside from the choices f intervention, asthma management is all about limiting the triggers managing the symptoms and helping to maintain function. Helping the individuals to avoid hospital visits, experience adverse effects of medication are also important.

You should keep in mind that there are a small number of steps that it is worth either undertaking directly with your patient or referring them to their GP or specialist.

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In one more of the rapidly developing field of immunotherapy in the treatment of allergy by training the oral tolerance mechanisms in our bodies, a group of 22 children (median age 11) with peanut allergies were fed under medical supervision a dose of peanuts made into flour and mixed in chocolate over several months.[1]

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Reading Time: 4 minutes

Many people suffer from an allergy to cow’s milk and other common foods, and whilst avoidance of the trigger has long been seen as the gold standard of management an evolving mechanism for treatment is being developed using oral tolerance triggers to restore food exposure competence.

Studies in several clinical trials in allergen-sublingual immunotherapy (SIT) have demonstrated that the induction of a tolerant state against allergens in many ways represents a key step in the development of a healthy immune response against allergens. Several cellular and molecular mechanisms have been demonstrated: allergen-specific suppressive capacities of both inducible subsets of CD4(+) CD25(+) forkhead box P3(+) T-regulatory and IL-10-secreting type 1 T-regulatory cells increase in peripheral blood; suppression of eosinophils, mast cells, and basophils; Antibody isotype change from IgE to IgG4.[1]

Reading Time: 3 minutes

A food allergy is defined as an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food.

New guidelines from an expert panel sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) aim to standardise the diagnosis and management of food allergy across clinical care settings.[1] The recommendations also addressed the use of multiple types of tests for reaching a diagnosis for IgE-mediated food allergy:

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Brief Explanation of Food Allergy

Monday, 29 November 2010 by
Reading Time: 3 minutes

From a medical perspective food allergy is an immunoglobulin (Ig)E- or non-IgE-mediated immune response to food protein. This small review will look at the IgE mediated food represented by immediate hypersensitivity (Gell-Coombs Type I), which can include anaphylaxis and can be life-threatening.

Food or environmental exposures that result in non-IgE-mediated reactions are thought to be cell mediated (allergic eosinophilic esophagitis/gastroenteritis, food protein-induced proctocolitis, food protein-induced enterocolitis syndrome, food protein-induced enteropathy; including coeliac disease).

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