Targeting NLRP3

Friday, 02 August 2019 by

Targeting-NLRP3According to the World health Organization noncommunicable diseases (NCDs), otherwise known as chronic diseases, are responsible for 71% of deaths globally, this shift away from death as a result of infectious diseases has occurred in most industrialised nations over the last century. Most NCDs occur later in life and are the result of a combination of genetic, physiological, environmental and behaviour factors.

indexThe growing knowledge in research communities concerning the symbiotic relationship we have with our bacterial organism population is increasingly reflecting that which we have been discussing for many years – namely the use of antibiotics (and many of our current lifestyle habits) is not a benign event in terms of microbiome outcomes. It seems that even short pulses of widely used antibiotics (amoxicillin and tylosin in this paper) can lead to long-term development changes in mouse pups, including increased body mass and bone growth and changes to the gut microbiota, according to a study published in Nature Communications.[1]