Grape seed extract by no means is “new” to the nutraceutical world, however, we are learning more about the potential broad benefits of this antioxidant-like nutritional compound, and starting to gain broader knowledge of mechanisms by which individual responses to this substance may vary. Grape seed extract is high in antioxidants in the form of polyphenols, which contribute to its potential therapeutic action.[i]  Resveratrol, the grape’s greatest claim to fame, is found primarily in the skins of grapes, with gallic acid, catechin, and epicatechin being the main polyphenols found in GSE.[ii] The amount of each of these substances in Grape seed extract varies widely by the variety of grape from which the seeds are sourced. Studies have shown that some of the compounds sourced from grapes, such as catechin and epicatechin, have a synergistic antioxidant effect.[iii]