Associated with the recent World Health Day of 8th April 2016 the first “Global Report on Diabetes” was published by the World Health Organization (WHO). The statistics on diabetes highlighted in this publication are alarming: diabetes has almost quadrupled since 1980 from 108 million to an estimated 422 million adults; diabetes is the number one cause of death, with 1.5 million people directly dying associated with diabetes in 2012. More than 43% of these deaths occurred in individuals under the age of 70 years old. The increase in type-2 diabetes (T2DM) has been observed to mirror the increasing prevalence in individuals who are overweight and obese. These numbers are also concerningly high, with 1 in 3 adults over the age of 18 being overweight and 1 in 10 being obese.
- Published in Reviews
I have previously written about the evolving spread of obesity and the consequences to human health due to the expansion of adipose tissues – that are in themselves promoters of inflammation via adipokine production.
Obesity has become a major worldwide health problem, not least because it is strongly associated with a number of diseases, including insulin resistance, type 2 diabetes, atherosclerosis and ischaemic heart disease, that reduce life expectancy and together have huge economic and societal consequences. Increasing evidence indicates that obesity is causally linked to a chronic low-grade inflammatory state which contributes to the development of obesity-linked disorders, in particular to metabolic dysfunction. It is now well established that adipose tissue is not only involved in energy storage but also functions as an endocrine organ that secretes various bio-active substances.
- Published in Reviews
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Inorganic lead is undoubtedly one of the oldest occupational toxins and evidence of lead poisoning can be found dating back to Roman times. It is a contaminating metal that has received much attention as the causative agent of one of the significant silent types of poisoning in the modern world. Industrial lead production started at
- Published in Abstracts
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