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IBD’s are characterised by wasting and chronic intestinal inflammation induced by many different cytokine-mediated pathways. It is clearly recognised that medical and surgical interventions do not cure Crohn’s disease because relapse is the rule after remission.

Until a few years ago, IBD was classified into Th1-dependent, that is, Crohn’s disease, and Th2-dependent, that is, ulcerative colitis, phenotypes. However, in recent years, it has been shown that new T-cell subclasses, that is, Th17 and regulatory T cells (TR), exist independently of Th1 and Th2 and that they play a central role in modulating IBD.

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2009coverBreast cancer survivors might be able to reduce their risk for contralateral breast cancer by making lifestyle modifications. A new study published online September 8 in the Journal of Clinical Oncology has found that obesity, alcohol use, and smoking all significantly increase the risk for second primary invasive contralateral breast cancer among breast cancer survivors.

Researchers from the Fred Hutchinson Cancer Research Center in Seattle, Washington, found that obese women had a 50% increased risk for contralateral breast cancer, and those who consumed 7 or more alcoholic drinks per week had a 90% increased risk. Survivors who currently smoked had a 120% increased risk of developing a second breast cancer.

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coverThe optimal status for Vitamin D is unlikely to be met without the ingestion of Vit D supplements. This is in part because the minimum levels are being revised upwards and the suitable food sources are inadequate in nutrient density and are erratically consumed. In addition the change in sunbathing practices in the northern hemisphere has led to a widely recognised Vit D deficiency pandemic.

Children are especially vulnerable to the adverse consequences of Vit D deficiency during their growing years. Recognising the need for supplemental intervention a group of clinicians and scientists from Divisions of Adolescent Medicine and Endocrinology, Children’s Hospital Boston, and Biotics Research Corporation explored the effectiveness of differing forms of Vit D3 in the restoration of normal levels of Vit D status in children.

Reading Time: 12 minutes

front cover Focus sept 2009

Michael E. Ash, BSc.(Hons) DO. ND. F.Dip ION has written an overview from a clinical perspective of the emerging science related to the mucosal immune system and the health of the brain in relation to affect. Published by the in house journal from Allergy Research Group it provides a strategic approach to managing individuals using a novel probiotic strategy.

From our early days in utero until we die, the ability of the GI tract to renew and replenish itself and maintain a stable relationship with trillions of bacteria is astounding. On a typical day the innate immune system of our gastrointestinal tract will process more immunological information than the rest of our body in its entire lifetime. It’s an absolute immunological miracle we can consume antigenic particles of food and not drop down dead every time we do so.

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2009coverPancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer.

Dr Gonzalez, a recent expert speaker at one of the NL expert education seminars, has had his therapy heavily criticised in this recent article published in the  respected Journal of Clinical Oncology.

At first sight it can seem that the paper roundly demolishes the pancreatic enzyme and lifestyle treatment recommended by Dr Gonzalez, and adds considerable value to the mixed chemotherapy treatment provided as the competing arm of the therapy.

In fact this paper has already been lauded in the arenas frequented by the more committed anti-alternative or non RCT evidenced medicine as a gross failure of the enzyme therapy to show any benefit in the care of pancreatic cancer patients.

Surely this must be considered an experts review, especially as the lead author Dr John Chabot was the appointed independent trial Principal Investigator at Columbia? He would know and report accurately what went on – wouldn’t he?

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00bookDiindolylmethane (DIM)
A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial oestrogen metabolism in both sexes by reducing the levels of 16-hydroxy oestrogen metabolites and increasing the formation of 2-hydroxy oestrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. Check for active clinical trials using this agent. (NCI Thesaurus)

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cover-mediumUse of benzodiazepine anti-anxiety drugs (like Valium) reached epidemic proportions two decades ago, the use of which was enshrined in the Rolling Stones song ‘Mothers Little Helper’. While long-term side effects have led to a significant decrease in use in recent times, modern benzodiazepine derivatives are still widely prescribed.

Drugs vs. Nutrients
Although nutritional approaches to anxiety have not seen much use by the medical profession, consumers have obtained some degree of anxiolytic relief through the use of such OTC items as B-complex vitamins, magnesium, GABA, and herbs like valerian.

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dhssps-banner-home-leftA year-long pilot scheme (2007/08) in Northern Ireland found impressive health benefits for patients offered complementary and alternative medicine (CAM) via the public health service.

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S0091674909X00102_cov200hDr Harri Hemila MD. PhD responded to the CAM article in Allergy and Clinical Immunology [1] stating-

Mainardi et al[1] reviewed the use and effects of complementary and alternative medicines on respiratory symptoms. They stated that early studies on vitamin C did not demonstrate an effect on the duration or intensity of the common cold, and as a support to this statement, they referred to 2 articles from 1975.[2,3]

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generic.Par.0001.ImageDr Harri Hemila MD PhD co author of the Cochrane Review article replies [1]:

The Cochrane review was limited to placebo-controlled trials in which at least 0.2 g of vitamin C was used per day.[2] Most of these trials examined vitamin C administration as regular supplementation and provided strong evidence that vitamin C shortens the duration of colds and alleviates its symptoms.

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