Picture the world in 2050. A demographic shift towards older age that began generations ago will have reached its peak, and 2 billion individuals will be aged 60 and older. In the United States and much of Europe, one in three persons will be in this old-age demographic (compared with one in five today). It is increasingly clear that the common mental disorders of emotion—anxiety disorders and unipolar depression—are a terrible scourge across the lifespan: they not only induce significant misery and suffering for the patient and his/her whole family, but with increasing age they become increasingly deleterious to health and cognition, even increasing mortality risk in older adults. Given such deleterious effects, understanding the common mental disorders in this large and growing demographic would seem to be a practical question of some importance. Anxiety is a ubiquitous experience amplified during lifespan, rooted in genetic determinants that evolved over millennia to complement the natural desire to survive in an unknown world. However, these triggers are frequently exceeding a level that exceeds easy compensation and adaption.
- Published in Reviews
Approaches to Curing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical Sensitivity, Gulf War Syndrome and Possibly Many Others by Martin L. Pall, PhD
From the Townsend Letter
February / March 2010
The NO/ONOO− cycle is a biochemical vicious cycle that is thought to cause such diseases as chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), multiple chemical sensitivity (MCS), fibromyalgia (FM), and possibly a large number of other chronic inflammatory diseases. The chemistry/biochemistry of the cycle predicts that the primary mechanism is local such the depending on where it is localized in the body, it may cause a variety of different diseases. Previous studies have shown that agents that lower such cycle elements as oxidative stress, nitric oxide, inflammatory responses, mitochondrial dysfunction, tetrahydrobiopterin (BH4) depletion and NMDA activity produce clinical improvements in CFS/ME and FM patients, consistent with the predictions of the cycle mechanism. Multiagent protocols lowering several aspects of the cycle appear to be the most promising approaches to therapy. These include an entirely over-the-counter nutritional support protocol developed by the author in conjunction with the Allergy Research Group. However, such
- Published in Reviews
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