Jan 2017 saw the publication of a review article on the potential role of Vitamin D as a risk factor in the development in the generation of autoimmune disorders.[1]

In the last few years, more attention has been given to the “non-calcaemic” effect of vitamin D. Several observational studies and meta-analyses demonstrated an association between circulating levels of vitamin D and outcome of many common diseases, including endocrine diseases, chronic diseases, cancer progression, and autoimmune diseases.

Vitamin D supplementation, and what levels to use are common discussions amongst Nutritional Therapists. I have written a number of commentaries and reviews on this subject over the last couple of years and a recent paper published in the Journal: Joint Bone Spine presents a very interesting take on mega supplementation to restore Vit D status.[1]

Rather than looking at the results as a directive for vigorous upfront Vit D supplementation, as there are obvious considerations that make this as a universal approach very questionable, it remains clinically relevant, and may provide a degree of confidence. What is of greater interest is the rapidly declining levels of serum 25-hydroxy vitamin D (25OHD) after the first month and the differences noted in the weight of the patient.