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April of 2013 FOCUS introduced the latest research on mixed tocotrienols from organic virgin red palm oil, and in November 2013 we further explored these novel molecules. We feel the quote from Bharat B. Agarwahl, PhD, of the University of Texas M.D. Anderson Cancer Center in Houston, sums it up well: “Tocotrienols exhibit health benefits quite different from that of tocopherols, and in most cases, these activities are superior for human use. Promising oral agents like tocotrienols are bioavailable, work on multiple pathways, and are already recognised as safe.”

Introduction: The mevalonate pathway is a hotbed of new research. It is best known to us through statins—which interrupt and downregulate the pathway at an early step, and thus lower cholesterol. But now scientists are realizing that this profoundly important cellular pathway is responsible for far more than the synthesis of cholesterol. It helps synthesize many highly significant molecules that impact health and disease, and influences vasoconstriction, inflammation, coagulation and oxidation.

Building Bone: The Novel Role of Tocotrienols

Thursday, 24 April 2014 by | Comments: 1

An Interview With Professor Dr. Ima-Nirwana Soelaiman, MBBS, PhD, Deputy Dean (Research and Innovation) Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Biography: The focus of Dr. Ima-Nirwana’s research is the impact of natural products on bone metabolism and osteoporosis, with special emphasis on tocotrienols. Dr. Ima-Nirwana has published 122 articles in scientific journals. Together with her team she has presented her work at over a hundred local and international conferences.  The results from her animal studies have consistently shown that tocotrienols can prevent and reverse osteoporosis due to stressors, including menopause, estrogen and androgen deficiency, steroid excess, nicotine exposure and oxidative stress and inflammation. She is currently planning clinical trials on tocotrienols and osteoporosis in the USA and in Malaysia. She is a member of the Malaysian Osteoporosis Society and the Malaysia Endocrine and Metabolic Society. She holds a patent within Malaysia for the use of tocotrienol for bone health in humans.

Prof. Dr Chandan a world expert on the role of tocotrienols and their role in health presented a short presentation in 2013 on the many benefits that can be attributed to the ingestion of Tocotrienols, we have discussed the interesting role of these vitamin E rich fats for the management of risk/prevention and recovery. In particular the reduction of stroke risk and the restoration of liver quality in people with fatty liver diseases or even greater risk of liver failure. Watch his presentation.

A recently published study that shows the synergistic effect of oral supplementation of d-mixed tocotrienols and alpha-tocopherol in improving non-alcoholic steatohepatitis rats. Non-alcoholic steatohepatits (NASH) is the most extreme form of non-alcoholic fatty liver disease (NAFLD), resulting from the accumulation of triglycerides/fats (fatty liver), oxidative stress and inflammatory in the liver.

Marilyn Arguillas is a gastroenterologist with a special interest in liver diseases particularly non-al­coholic fatty liver disease, chronic hepatitis, cirrho­sis and liver cancer. She is chair of Internal Med­icine-Gastroenterology at Davao Doctors Hospital in Davao City, Philippines. She was a member of the Executive Council of the Asian Pacific Associa­tion for the Study of the Liver (APASL) from 2006- 2010 and the President of the Hepatology Society of the Philippines from 2010-2012. In June of 2013 her findings on tocotrienols and fatty liver disease were presented as a Poster of Distinction by the Asian Pa­cific Association for the Study of the Liver (APASL) conference in Singapore.

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Hidden in the stately steppes of gentle rice paddies, nestled in shiny clusters of red and purple palm fruit, lurking in tiny annatto seeds from the achiote tree… lies a quartet of potent anti-inflammatory, highly protective molecules called tocotrienols. They are cousins to the four tocopherols. Together, all eight comprise the Vitamin E family, a lipid-loving arsenal of molecules essential to health. Each has its own healing profile. According to molecular biochemist Chandan Sen, of Ohio State University, “Current studies of the biological functions of vitamin E continue to indicate that each member of the vitamin E family possesses unique biological functions often not shared by other family members.”[1]

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Hidden in the stately steppes of gentle rice paddies, lurking in shiny clusters of red and purple palm fruit, nestled in tiny annatto seeds from the achiote tree…lies a quartet of potent anti-inflammatory, highly protective molecules called tocotrienols. They are cousins to the four tocopherols. Together, all eight comprise the Vitamin E family, a lipid-loving arsenal of molecules essential to health. Each has its own healing profile. According to molecular biochemist Chandan Sen, of Ohio State University, “Current studies of the biological functions of vitamin E continue to indicate that each member of the vitamin E family possesses unique biological functions often not shared by other family members.”[1] 

By Michael Ash, BSc, DO, ND, F.DipIOn

One of my primary areas of research and expertise is the gut microbiota and its diverse impact on our health. Your liver receives nearly 70% of its blood supply from the intestine, and represents a first line of defence against gut-derived antigens. Intestinal bacteria—and the antigens they produce—play a key role in the maintenance of gut-liver axis health. Modulation of the gut microbiota to achieve and maintain symbiosis represents a new way to treat or prevent non-alcoholic fatty liver disease (NAFLD). Along with the concomitant use of tocotrienols and glycophospholipids, we may be starting to see the emergence of a truly profound intervention for a complex metabolic disease, using safe,natural compounds.

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