Gut Bacteria and Type 2 Diabetes

Friday, 26 June 2020 by | Comments: 1
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Gut-Bacteria-and-Type-2-DiabetesAccording to a study, published in Nature Metabolism in March 2020, #gut #bacteria can be linked to the development of type 2 #diabetes, with the authors finding that diabetics have a different bacterial signature in blood, liver and certain abdominal fat deposits to non-diabetics. The research group, based at Université Laval, Canada, examined tissue from 40 obese patients, half of whom had normal blood glucose levels, and half who had type 2 diabetes #T2D. T2D is highly prevalent worldwide and hugely compromises health and life span. With Diabetes UK, having found that one in ten people over the age of 40 in the UK are living with T2D, a figure set to rise over the coming years, this type of research is vital to a better understanding of the condition.

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6267.cover-sourceRecent studies have suggested that gut bacteria play a fundamental role in diseases such as obesity, diabetes and cardiovascular disease. Data are accumulating in animal models and humans suggesting that obesity and type 2 diabetes (T2D) are associated with a profound dysbiosis.[1]

First human metagenome-wide association studies demonstrated highly significant correlations of specific intestinal bacteria, certain bacterial genes and respective metabolic pathways with T2D. Importantly, especially butyrate-producing bacteria such as Roseburia intestinalis and Faecalibacterium prausnitzii concentrations were lower in T2D subjects.