Can proline-rich polypeptides (PRPs) protect your brain and even boost brain function? Studies in vitro on animals and humans support that idea. The neuro-protective cytokines in PRPs have a remarkably stabilizing effect on cognitive function in Alzheimer’s disease patients. In vitro studies show that PRPs inhibit fibrils and amyloid plaques.[1] PRPs also modulate intracellular levels of reactive oxygen species (ROS), by regulating glutathione metabolism and antioxidant enzymes.[2] Gene expression analysis found that PRPs down-regulate genes involved in inflammatory pathways and increase levels of an Amyloid-beta (Aβ) hydrolyzing enzyme.[3] When given orally to mice, PRPs improve motor and sensory activities.[4] When mice are given either PRPs or plain colostrum, the PRP supplemented mice swim faster to a hidden platform.[5] PRPs also improve spatial learning and memory in older rats.[6]