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Schematic representation of mechanisms accounting for mitochondrial outer membrane permeabilisation

by: Michael Ash BSc DO ND F.DipION+, Prof. Garth L. Nicolson, Ph.D.*

+Nutri-Link Clinical Education, Devon UK

*Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, CA 92647

If the fundamental biological maxim– ‘structure subserves function’ – remains paramount, the evolutionary commitment to generating, managing and maintaining the vast array of lipids required by humans to survive and prosper has presented science with a complex task to fully elucidate our lipid repertoire and determine their biological functions. .  Arguably the most important of these lipids are the phospholipids that are the mainstay of all cellular membranes. The wide variety of cellular and organelle membranes and the existence of special membrane lipid regions and domains allows for the design of specific lipid replacement therapies to support and maintain the structure and function of cellular membranes. The authors discuss some of the biological processes and evolving strategies related to lipid replacement therapy and its use along with antioxidants for the constitutive management of mitochondrial and other cellular membranes as well as the functional gains from the utilisation of lipid replacement to improve cellular membranes biological functions.

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