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Introduction: The mevalonate pathway is a hotbed of new research. It is best known to us through statins—which interrupt and downregulate the pathway at an early step, and thus lower cholesterol. But now scientists are realizing that this profoundly important cellular pathway is responsible for far more than the synthesis of cholesterol. It helps synthesize many highly significant molecules that impact health and disease, and influences vasoconstriction, inflammation, coagulation and oxidation.

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