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Chronic Fatigue Responds to Antioxidants

Monday, 08 February 2010 by | Comments: 9
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Many researchers have investigated effective treatments for chronic fatigue syndrome (CFS) and multiple chemical sensitivity (MCS), but Martin Pall, Ph.D., Professor Emeritus of Biochemistry and Basic Medical Sciences at Washington State University, and author of Explaining “Unexplained Illnesses”, is the first to suggest a plausible underlying cause and therapeutic method of treatment. Pall, who came down with a severe case of CFS in 1997 and fully recovered in 18 months, has dedicated the rest of his career to understanding and treating these illnesses.

Pall has discovered that abnormal levels of nitric oxide (NO), high levels of peroxynitrite (ONOO-) and superoxide activate the disabling and widely varying symptoms that characterise this entire group of unexplained illness. The fundamental approach: reducing NO-related free radical activity.

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623059A recent paper on sauna therapy by Dr. Martin L. Pall argues for a novel mechanism for its mode of action (1).  Pall argues that sauna therapy acts primarily by increasing the availability of a compound called tetrahydrobiopterin (BH4) in the body.  BH4 is reported or thought to be depleted in a number of medical conditions that are also reported to respond positively to sauna therapy, including multiple chemical sensitivity, fibromyalgia, chronic fatigue syndrome, hypertension, vascular endothelial dysfunction and heart failure.  This pattern of action can be explained, therefore, if sauna therapy increases the availability in the body of BH4.

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Prof Martin Pall of Washington State University has been exploring the biochmical mechanisms behind the complex illness known as Multiple Chemical Sensitivity. He states: Cases of multiple chemical sensitivity (MCS) are reported to be initiated by seven classes of chemicals. Each of the seven acts along a specific pathway, indirectly producing increases in NMDA (A

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