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The trace element zinc is essential for the immune system, and zinc deficiency affects multiple aspects of innate and adaptive immunity. There are remarkable parallels in the immunological changes during aging and zinc deficiency, including a reduction in the activity of the thymus and thymic hormones, a shift of the T helper cell balance toward

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The milieu and array of inflammatory cells and inflammatory mediators are crucially involved in the genesis, persistence and severity of pain following trauma, infection or nerve injury [1]. The mechanisms and pathways mediating pain and nociception (hyperalgesia) are transcriptionally regulated. The transcriptional mediator nuclear factor (NF)-κB plays a major role in regulating inflammatory responses, ostensibly via the control of gene expression/suppression. An association has recently emerged to establish a possible link between NF-kB and pain/nociception, purportedly through the regulation of the inflammatory loop and the secretion (biosynthesis) of pro-inflammatory mediators.

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Co-evolutionary development of the immune system together with infections and non-infectious environmental proteins (allergens) has generated biologically relevant thresholds and major directions to be taken by the immune system. The default healthy immune response to allergens is expected to be no response, however, detectable T cell and antibody (particularly IgG4 and IgG1) response has been demonstrated in sensitized, but clinically healthy individuals. If an immune response develops in healthy individuals, the immune system shows allergen-specific tolerance by using multiple mechanisms in order to keep the intensity of the inflammation low and tissue destruction small.

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The most devastating loss of life from breast cancer impacts women between the ages of 30 and 50. For women between the ages of 40 and 44, breast cancer is the leading cause of death, according to the American Cancer Society. Yet the November 10, 2003 issue of the AMA journal, American Medical News, reports

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Recent findings suggest that the amino acid glutamine reduces Helicobacter pylori-associated pathology in mice and may therefore have similar effects in humans with gastric ulcers caused by H. pylori.

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Comment: Researchers found that local intestinal inflammation induced DNA damage to lymphocytes of the peripheral blood circulating throughout the body. This means that chromosome damage was not limited to the intestine, but involved tissues of the body distant from the site of inflammation. The chromosome damage in the peripheral circulating blood could be used as

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An imbalance in bone formation relative to bone resorption results in the net bone loss that occurs in osteoporosis and inflammatory bone diseases. Although it is well known how bone resorption is stimulated, the molecular mechanisms that mediate impaired bone formation are poorly understood.

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Comment: Chronic inflammation is known to be associated with increased episodes of heart attacks and with such autoimmune disorders as diabetes, lupus, rheumatoid arthritis and multiple sclerosis among others. One way to fight such inflammation is through nutrition – and specifically, as researchers from the University of Bonn and the ETH Zurich have discovered, by including oregano in our diets.

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Comment: Nearly 20 years ago, it was discovered that bacteria known as Helicobacter pylori were responsible for stomach ulcers. Since then, antibiotics have become the primary therapy used to combat the H. pylori infection, which affects approximately six percent of the world population and is also a primary cause of stomach cancer. But today the bacteria is growing increasingly resistant to antibiotics.

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A new study indicates there may be yet another reason to reduce childhood obesity — it may help prevent allergies. The study published in the May issue of the Journal of Allergy and Clinical Immunology showed that obese children and adolescents are at increased risk of having some kind of allergy, especially to a food. The study was funded by the National Institute of Environmental Health Sciences (NIEHS) and the National Institute of Allergy and Infectious Diseases (NIAID), both parts of the National Institutes of Health.

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