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front-cover-Focus-sept-2009New Research Reveals Probiotic’s Anti-Toxin, Anti-Inflammatory, Immune Boosting Properties

Lactobacillus GG is the most prolifically researched probiotic in the world—over 400 studies have been published that document its remarkable immune-modulating properties.This unique immunobiotic was isolated from a healthy human in 1985 by a team of two Tufts University researchers,Barry Goldin, M.S., Ph.D. and Sherwood L. Gorbach, M.D. They spent nearly a decade testing organisms until they discovered one that was a potent antimicrobial, survived stomach and bile acid, and was very, very sticky—it adhered well to the gut mucosa.

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IBD’s are characterised by wasting and chronic intestinal inflammation induced by many different cytokine-mediated pathways. It is clearly recognised that medical and surgical interventions do not cure Crohn’s disease because relapse is the rule after remission.

Until a few years ago, IBD was classified into Th1-dependent, that is, Crohn’s disease, and Th2-dependent, that is, ulcerative colitis, phenotypes. However, in recent years, it has been shown that new T-cell subclasses, that is, Th17 and regulatory T cells (TR), exist independently of Th1 and Th2 and that they play a central role in modulating IBD.

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coverThe optimal status for Vitamin D is unlikely to be met without the ingestion of Vit D supplements. This is in part because the minimum levels are being revised upwards and the suitable food sources are inadequate in nutrient density and are erratically consumed. In addition the change in sunbathing practices in the northern hemisphere has led to a widely recognised Vit D deficiency pandemic.

Children are especially vulnerable to the adverse consequences of Vit D deficiency during their growing years. Recognising the need for supplemental intervention a group of clinicians and scientists from Divisions of Adolescent Medicine and Endocrinology, Children’s Hospital Boston, and Biotics Research Corporation explored the effectiveness of differing forms of Vit D3 in the restoration of normal levels of Vit D status in children.

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front cover Focus sept 2009

Michael E. Ash, BSc.(Hons) DO. ND. F.Dip ION has written an overview from a clinical perspective of the emerging science related to the mucosal immune system and the health of the brain in relation to affect. Published by the in house journal from Allergy Research Group it provides a strategic approach to managing individuals using a novel probiotic strategy.

From our early days in utero until we die, the ability of the GI tract to renew and replenish itself and maintain a stable relationship with trillions of bacteria is astounding. On a typical day the innate immune system of our gastrointestinal tract will process more immunological information than the rest of our body in its entire lifetime. It’s an absolute immunological miracle we can consume antigenic particles of food and not drop down dead every time we do so.

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2009coverPancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer.

Dr Gonzalez, a recent expert speaker at one of the NL expert education seminars, has had his therapy heavily criticised in this recent article published in the  respected Journal of Clinical Oncology.

At first sight it can seem that the paper roundly demolishes the pancreatic enzyme and lifestyle treatment recommended by Dr Gonzalez, and adds considerable value to the mixed chemotherapy treatment provided as the competing arm of the therapy.

In fact this paper has already been lauded in the arenas frequented by the more committed anti-alternative or non RCT evidenced medicine as a gross failure of the enzyme therapy to show any benefit in the care of pancreatic cancer patients.

Surely this must be considered an experts review, especially as the lead author Dr John Chabot was the appointed independent trial Principal Investigator at Columbia? He would know and report accurately what went on – wouldn’t he?

Common Ills are Linked to Memory Loss

Friday, 25 September 2009 by
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coverPatients with Alzheimer’s disease who have common bacterial infections suffer greater memory loss, claims a recent study published in Neurology. The effect is said to be linked to increased levels of the pro-inflammatory cytokine tumour necrosis factor (TNFa) caused by systemic inflammation.

Previous research has suggested that acute systemic inflammation might exacerbate neurodegeneration, so the researchers, based at the University of Southampton, UK, measured the level of TNFa in the blood of 222 elderly people with Alzheimer’s disease and assessed their ability to perform cognitive tests over a 6 month period.

H1N1 (Swine Flu) What Does it Mean This Winter?

Monday, 21 September 2009 by | Comments: 1
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ECDC_logoThe European Centre for Disease Prevention and Control recently surveyed H1N1 (Swine Flu) epidemiological 2009 data for 28 countries, finding that 51% of all deaths have been among people aged 20-49 years, and only 12% were among people over 60 years of age.

This is striking, as it is a near-perfect reverse of normal flu trends, and mirrors what was seen, demographically, in 1918. While the  President’s Council of Advisors on Science and Technology have tried to factor in such trends, it is extremely difficult to know how influenza dynamics, illnesses and death rates may vary if transmission and illness is primarily among young adults.

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S1074761309X00099_cov150hFoxp3+ T regulatory (Treg) cells control all aspects of the immune response. This paper reviews the in vitro model systems that have been developed to define the mechanisms used by Treg cells to suppress a large number of distinct target cell types.

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00bookDiindolylmethane (DIM)
A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial oestrogen metabolism in both sexes by reducing the levels of 16-hydroxy oestrogen metabolites and increasing the formation of 2-hydroxy oestrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. Check for active clinical trials using this agent. (NCI Thesaurus)

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