By Antony Haynes BA, Registered Nutritional Therapist
The word ‘homocysteine’ has entered the lexicon of familiar words over the past decade, at least for health practitioners, as has the term methylation, and the two are intimately connected.
What is Methylation?
Methylation denotes the addition of a methyl group on a substrate, or the substitution of an atom (or group) by a methyl group. Methylation is a form of alkylation, with a methyl group, rather than a larger carbon chain, replacing a hydrogen atom. Methylation is catalysed by enzymes.
- Published in Reviews
If Alzheimer’s is a disease related to adverse inflammatory responses over time, could one of the largest and most regular antigenic burden – our foods have a significant impact on risk of development. What level of conviction would we as humans looking at a future of declining cognitive function require to moderate our food selection.
The journal Archives of Neurology in April 2010 published a paper looking at the role of a protective diet over time on the risk of Alzheimer’s development in northern Manhattan, New York.
As humans we are prone to wide food selection and isolated or synergistic combination become complex. To try and resolve a methodological error risk, this group used an alternative strategy called dietary pattern analysis. Instead of looking at individual nutrients or foods, pattern analysis examines the effects of overall diet.
A group of 2,148 older adults (age 65 and older) without dementia living in New York were selected. They provided information about their diets and were assessed for the development of dementia every 1.5 years for an average of four years. Several dietary patterns were identified with varying levels of seven nutrients previously shown to be associated with Alzheimer’s disease risk:
- Published in Abstracts
Research: In this study, researchers measured blood levels of total homocysteine ((t)Hcy), vitamin B(12) and folic acid in patients with Parkinson s disease (PD) and in age-matched controls, and searched for possible associations between these levels with smoking, alcohol consumption, L-DOPA treatment and disease duration in PD patients.
- Published in Abstracts
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