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cover_natureA study in Nature suggests that common food additives could be contributing to the development of chronic inflammatory diseases. Chassaing et al.[1] report that dietary emulsifiers induce low-grade inflammation in mice by disrupting the composition of their intestinal microbiota, thereby predisposing these animals to the development of metabolic syndrome and colitis. This builds on an earlier paper they published in the Journal of Toxicologic Pathology.[2]

To explore the effects of emulsifying agents on the intestinal mucosa, the authors administered carboxymethylcellulose (CMC) or polysorbate 80 (P80), which are emulsifiers commonly used in human foods, to mice in their drinking water. Compared with control mice, animals that received the emulsifiers showed reduced mucus thickness and increased gut permeability.

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A possible link between what a mother eats during pregnancy and the risk of her child developing allergies has been identified in new research published in Septembers; The Journal of Physiology.[1]

This paper identified that if the maternal diet is rich in PUFA’s or poly unsaturated fats such as those found in flaxseed, walnuts and fish their offspring’s digestive tract develops differently than in those progeny lacking these PUFAs.

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The unfolding of bacterial homeostasis in the gut continues apace and with each new stone uncovered there are interesting pathways that provide avenues for exploration and explanation in the management of inflammatory bowel diseases and functional disorders.

A paper out in Science[1] has identified that the protein β-catenin has an important role to play in inflammation control (β-catenin is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells) plays an important role in the management of mucosal tolerance.

β-catenin signalling promotes the induction of regulatory T (TReg) cells while suppressing T helper 1 (TH1) and TH17 cells in the gut by maintaining intestinal dendritic cells (DCs) in a tolerogenic state.

LGG Attenuates Barrier Permeability In The Gut

Tuesday, 13 July 2010 by | Comments: 1
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Increased gut permeability as discussed in other posts has been linked with symptoms far from the gut and include depression, arthritis, diabetes and other conditions in which a pro inflammatory milieu is being maintained. Some immunologists now refer to this low grade inflammation as Para-Inflammation. Locally, the barrier defect can contribute to diahorrhea and chronic inflammatory bowel diseases.

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