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Introduction

There is a simple arithmetic to human life that holds deep insights into health and disease—the rate of our cell generation minus the rate of our cell loss determines the growth or degeneration of a tissue.

Recent evidence indicates that the interplay between our mitochondria, mitophagy (the removal of impaired mitochondria by a specialised version of the autophagy pathway by delivering mitochondria to the lysosomes for degradation) and autophagy links aging to health or disease.[1]

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