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As part of a nutritional strategy to impart improvements to mucosal barrier in compromised patients the use of a naturally occurring growth factor has been explored in many studies and in some supplements in clinical use. Glandular extract derived from bovine sources that contributes epithelial growth factor (EGF) offer an additional strategy for epithelial tissue repair. EGF is a normal constituent of saliva production during the act of eating, is also secreted into the gut lumen and found in colostrum and milk. The purpose is to aid in the management of epithelial tissue health and it is naturally degraded by pancreatic enzymes during digestion.

The amino acid L-Arginine is suspected through animal models to increase intraluminal production of EGF and may explain why this protein is a useful method for repairing intestinal damage.[1]