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Vit C For Heart Health

Tuesday, 01 July 2014 by
Reading Time: 2 minutes

In a paper published in the journal Atherosclerosis, the authors of the published article – Effect of vitamin C on endothelial function in health and disease: A systematic review and meta-analysis of randomised controlled trials.[1]  identified a specific improvement in one aspect related to arterial/vascular health, namely endothelial function.

The normal artery contains three layers. The inner layer, the tunica intima, is lined by a monolayer of endothelial cells (EC) that is in contact with blood. The middle layer, or tunica media, contains smooth muscle cells embedded in a complex extracellular matrix. The adventitia, the outer layer of artery, contains mast cells, nerve endings and microvessels. The direct contact of ECs with the blood flow means that they are particularly vulnerable to damage molecules in the blood on one hand, and that they have ideally “guard” roles on the other hand (i.e., sensing alterations in perfusate constituents and either responding directly or transmitting reactive signals to nearby cells, such as smooth vascular cells).

Consequently endothelial dysfunction contributes to the development of nearly all vascular diseases.

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