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How the Endocannabinoid System Interacts with the Hypothalamic-Pituitary-Adrenal Axis to Modulate the Stress Response by Dr Carrie Decker ND With as much attention as the endocannabinoid system is receiving for its role in the modulation of pain,[1] mood,[2] inflammation, and immune system response,[3] a discussion of the body’s stress response would be incomplete without mention