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An article in the New England Journal of Medicine, January 2013 explores the validity of faecal transplant therapy for the resolution of C. difficile therapy and reminds us that back in 1958 clinicians in Denver trialled this therapy to “re-establish the balance of nature” within the intestinal flora to correct the disruption caused by antibiotic treatment.[1]

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I have written a number of times about the role of faecal transplantation in the established intervention for Clostridium difficile and have hinted at the possible cross mechanism benefits of inducing commensal bacteria that favour tolerance into the gastrointestinal tract. The implication being, that individuals experiencing illness driven by loss of immunological tolerance, not simply within the digestive tract, but systemically may benefit from an evolutionary transplant.

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