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The microbiota and the heartThe department of Immunology from the University of Toronto have recently completed research into the origins and causes behind inflammation of the heart (#myocarditis). Whilst many other studies have been conducted, resulting in a variety of theories, there has not yet been a conclusive definition of how risk factors and environmental exposures intersect. The Toronto team have shown in their results that genetic predisposition, production of a commensal #gut #microbial #autoantigen, and systemic #inflammation combine to trigger the generation of autoreactive CD4+ T cells that cause autoimmune myocarditis and #cardiac dysfunction.

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