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Apples Can Suppress IBD

Monday, 12 December 2011 by | Comments: 2

Here’s another reason why “an apple a day keeps the doctor away”—according to new research findings published in the Journal of Leukocyte Biology (https://www.jleukbio.org), oral ingestion of apple polyphenols (antioxidants found in apple peels) can suppress T cell activation to prevent colitis in mice.[1] This study is the first to show a role for T cells in polyphenol-mediated protection against an autoimmune disease and could lead to new therapies and treatments for people with disorders related to bowel inflammation, such as ulcerative colitis, Crohn’s disease and colitis-associated colorectal cancer.

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In the context of the ever increasing relationship between inflammation and diseases of our western lifestyle the idea that the old adage of ‘an apple a day keeps the Dr away’ this recent paper has some attractive evidence.

The university of Illinois team of researcher have written a paper due to be published in the prestigious Journal Brain Behaviour and Immunity later in the year around May.[1]

Looking at a mouse model – and we are aware of how diet affect mouse studies from a post written a few days ago- Food Choice Affects Lab Outcomes this group have extended the concept further, and presented the mice with a specially enriched diet. This study fed a low fat diet to both groups for six weeks differentiated by one having soluble fibre and the other non soluble fibre.

When challenged using a microbial wall particle called lipopolysaccharide (LPS) the group on the soluble fibre had a 50% reduction in symptoms compared to the insoluble group. They also recovered 50% faster. It seems that just 6 weeks of an increased soluble fibre intake change their immune responses in a very positive manner.

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