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In an allied review I have discussed the evolving role of epigenetics as the valued mechanism for explaining how gene expression rather than DNA change determines and mediates risk for complex health problems. In addition epigenetics helps to explain cross generational exposure transmission and why despite their being less than 1% variation in human DNA between individuals they can experience significant differences in health and function.

Great hopes were pinned on the discovery of our DNA yet as discussed in a related post we have less DNA than a grape and certainly less than was originally thought, just slightly more than a humble fruit fly in fact – so surely DNA cannot carry all of our aspirations and risk within that elegant double helix.