Four Candida species, C. albicans, C. glabrata, C. tropicalis and C. parapsilosis, together account for 95% of identifiable Candida infections. Although C. albicans is still the most common causative agent, its incidence is declining and the frequency of other species is increasing. Of these, C. parapsilosis is a particular problem in neonates, transplant recipients and patients receiving parenteral nutrition; C. tropicalis is more commonly associated with neutropenia and malignancy. Other Candida species, including C. krusei, C. lusitaniae and C. guilliermondii, account for <5% of invasive candidiasis. Almost all Candida species, with the exceptions of C. glabrata and C. krusei, belong in a single Candida clade.
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