Immunosenescence and how to manage it

Wednesday, 18 August 2021 by
Reading Time: 6 minutes

Immunosenescence-and-how-to-manage-itFeeling old? Consider the redwoods in the USA. Reaching heights of more than 350 feet, the world’s tallest trees have been on this planet since the days of the dinosaurs. A single specimen can live more than 2,000 years. That’s old enough to make it through from the Roman Empire to the British Empire and an assortment of presidents and prime ministers! Yet the mycelial population that connects all trees and arguably is the formative source of all life, is even older.

Vaccine and Wild Type Immune Preparedness

Thursday, 15 April 2021 by | Comments: 1

Reading Time: 6 minutes

Published 17th February 2021 Ayurvedic proverb: “When diet is wrong, medicine is of no use; when diet is correct, medicine is of no need.” The shift in messaging since the allocated timeline for 15m vaccinations was achieved in the UK, is a fascinating process of dialogue and development. One can imagine that numerous pressures are

Happiness – Denied by Distraction – A Solution

Tuesday, 09 February 2021 by | Comments: 1
Reading Time: 7 minutes

happinessPublished 02 February 2021


The state of ‘being’, sought by all and yet when obtained, is generally all too temporary, is that of ‘happiness’. How are you in its pursuit and attainment?

In the 2020 World Happiness Report the authors note that in the face of a pandemic where the social fabric is not strong enough to support co-operative action on the required scale, then fear, disappointment and anger add to the happiness costs of a disaster. There are few people that have not experienced these costs over the last few months. (Practical, safe solutions are described at the end!)

Reading Time: 4 minutes

pascalPublished 21 January 2021

In the late 1650’s, the French polymath and renowned scientist Blaise Pascal, having undergone a religious experience that transformed him into something of a zealot, suggested the following logical strategy regarding belief in God: If there is a God, then believing in him will ensure you an eternity of bliss, while not believing in him could earn you an eternal sentence to misery.

On the other hand, if there is no God, believing in him anyway will cost you very little, and not believing in him will mean nothing in the non-existent after life. Therefore, the only sensible bet is to believe in God. This has come to be known as Pascal’s Wager.

The wager has a surprising number of applications beyond concerns for a comfortable afterlife. There are many things for which the value of believing something or not can be utilised as a ‘cost-versus-likely-benefit’ wager, often without regard to the actual truth of the matter.

Since science does not profess to have a final truth, and in many areas freely admits its incomplete knowledge, Pascal’s wager can provide a useful method of deciding between two alternatives. In this article it is the validity of the Sars-Cov-2 virus as a causative agent of global illness and the benefit or not of two of the most common non-pharmacological strategies and lifestyle proposals for its related management.

Where Next?

Tuesday, 09 February 2021 by
Reading Time: 4 minutes

Where-Next-9900000000079e3cPublished 17th December 2020


As we come to the end of a very different year, it is common practice to look back on events. Obviously the Sars-Cov-2 virus has featured heavily so let’s do a quick review:

Based on collated data from research and observational studies since Feb 2020 it is well understood that the SARS-CoV-2 virus spreads most efficiently among unmasked adult speakers who spend time together in close, unventilated indoor spaces. More so, if when in that space, they insist on talking to each other!

It is also clear that the virus can spread through nonverbal activities. Sneezing and coughing produce virus-encased globs of spittle, and even heavy breathing, especially during a run or vigorous activity, can spray aerosolised droplets that can linger in the air before slipping inside a person’s nose or mouth.  

The primary mechanism of transmission of SARS-CoV-2 is via infected respiratory droplets. Viral infection occurs by direct or indirect contact with nasal, conjunctival, or oral mucosa, when respiratory particles are inhaled or deposited on these mucous membranes. This clarifies that mucosal immunity, a barrier and site of adaptive immune triggering, needs to be in tip top condition to prevent infectious events occurring.

The virus however, despite initial concerns does not seem to spread reliably via surfaces. Put simply, COVID-19 is mostly a ‘talking disease’ one that could be better contained with appropriate universal mask wearing, a national campaign that emphasises quiet in public spaces, and clear determinations about indoor gatherings.

This proposal has been explored in Japan, for whilst much of the world emphasised the importance of testing and tracing (with the caveat that testing has limitations on accuracy and tracing has been especially poor in the UK), Japan initially had no mass testing and no sophisticated means of contract tracing. Yet, adjusted for population, the country currently has approximately 98 percent fewer COVID-19 deaths than the United Kingdom.

Much credit has gone to its crystal-clear public guidance to avoid the three C’s: Closed spaces, Crowded places, and Close-contact settings, including “Close-range conversations.” That’s not to say they have not had economic problems, but that there appears to be a strong relationship between social behaviour and risk of adverse outcomes, also seen in many other Asian countries approaches to management.

Reading Time: 2 minutes

Are-E-Cigarettes-Compromising-the-Gut-Barrier#E-Cigarettes have been marketed as the healthy alternative to conventional nicotine smoking, with millions of people now using them worldwide. Studies have already indicated that they have the potential to cause some damage to the lungs, but not nearly as much as tobacco cigarettes. Now new research from the University of California, published in iScience, has demonstrated, across several experiments, that e-cigarette vapour can weaken the #gut lining and lead to chronic #inflammation.

Reading Time: 2 minutes

Nutritional-Support-for-Parkinson’s-Disease#Parkinson’s disease is the fastest growing #neurological condition in the world, it is progressive and chronic and currently there is no cure. In its most advance stages, it can necessitate around the clock care, with patients experiencing both #motor and non-motor impairments. Published in the Journal of Restorative Medicine researchers from Maryland University of Integrative Health have recently reviewed several potentially beneficial foods and bioactive substances for patients with Parkinson’s disease (#PD), as well as those items that may contribute to or exacerbate symptoms.

Reading Time: 2 minutes

Proven-Link-Between-the-Microbiome-and-the-Dynamics-of-the-Immune-SystemIn recent years, the #microbiota has been linked to many aspects of human health, but until now its impact on the #immune system has only been assumed because of data from animal studies. Scientists from Memorial Sloan Kettering have now, for the first time, shown that the #gut #microbiome directly shapes the makeup of the human immune system, with the results of their study published in Nature.

Patrick Holford Seeks Your Support For Vitamin C

Tuesday, 01 December 2020 by | Comments: 2

Reading Time: 3 minutes

Dear practitioner Vitamin D is now firmly on the map for COVID-19 prevention but what about vitamin C? We urgently seek your support by means of a signature, for a timely and important initiative. Let me explain. My co-authors and I  (Professor Paul Marik – Chief of critical care medicine at East Virginia Medical School;

Reading Time: 2 minutes

Using-Adaptogens-to-Fight-Respiratory-InfectionsThe #COVID-19 pandemic has challenged biomedical scientists to develop effective therapeutics for the treatment and prevention of acute #viral diseases. Due to a lack of evidence into the safety and efficacy of herbal preparations their potential to aid in prevention and treatment has been underestimated. This is especially significant when the reality is that synthetic antiviral and immunotropic drugs generally have a higher risk of adverse effects than most herbal preparations.  Published by the Molecular Diversity Preservation International (#MDPI) journal is a review of The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections.