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Abstract: Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS). Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unknown. We evaluated the effects of a combination of vitamin C (1000 mg/day) and vitamin E (400 IU/day) on insulin sensitivity as measured by glucose infusion rates (GIR) during a hyperinsulinemic, euglycemic clamp in previously untrained (n = 19) and pretrained (n = 20) healthy young men. Before and after a 4 week intervention of physical exercise, GIR was determined, and muscle biopsies for gene expression analyses as well as plasma samples were obtained to compare changes over baseline and potential influences of vitamins on exercise effects.

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Facts do not accumulate on the blank slates of researchers’ minds and data simply do not speak for themselves. Good science inevitably embodies a tension between the empiricism of concrete data and the rationalism of deeply held convictions. Unbiased interpretation of data is as important as performing rigorous experiments. This evaluative process is never totally objective or completely independent of scientists’ convictions or theoretical apparatus.

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As prophylaxis against ventilator-associated pneumonia, the probiotic bacterium Lactobacillus plantarum 299 (Lp299) is as effective as the antiseptic chlorhexidine in reducing the pathogenic bacterial load in the oropharynx of tracheally intubated, mechanically ventilated, critically ill patients, results of a pilot study indicate.

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Comment: The National Institutes of Health have spent more than $2 billion researching complementary and alternative medicine (CAM). However, these studies may have little influence on mainstream physicians and even CAM providers, according to a survey reported in the April 13 issue of the Archives of Internal Medicine.

“In this study we wanted to know, ‘Can CAM research have social value?'” Dr. Jon C. Tilburt told Reuters Health. “We sought to answer this from the perspectives of the clinicians who might benefit from the published clinical trials of CAM.”

Dr. Tilburt, a bioethicist at the NIH in Bethesda, Maryland, and at the Mayo Clinic in Rochester, Minnesota, added, “Awareness of and willingness to recommend a therapy based on new evidence are preliminary indicators of whether or not CAM research is making its way into clinical practice.”

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ARG Focus – August 2010 – Why Vitamin D is Not Enough ARG Focus – October 2009 – The Age of Immunobiotics, Pall Research ARG Focus – March 2009 – Lumbrokinase, Hypercoagulation, Biofilms ARG Focus – November 2008 – Nattokinase, Zyactinase, Propionic Bacteria ARG Focus – July 2008 – Delta-Tocotrienol, Mastic, Glutathione ARG Focus –

Patients with functional gut disorders, irritable bowel disease, and related syndromes frequently attribute their symptoms to intestinal gas. While patients are usually convinced of their interpretation, the doctor has few arguments to confirm or refute it, and in this context intestinal gas has become a myth. Studies of intestinal gas dynamics have demonstrated subtle dysfunctions

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Comment: Of course, everyone would agree that all persons should be encouraged to eat a good diet, but we are far from achieving this goal, especially among the poor. In most cases, a simple way to improve micronutrient status is to take an MVM. However, even if one eats an ideal diet and takes an

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Inadequate dietary intakes of vitamins and minerals are widespread, most likely due to excessive consumption of energy-rich, micronutrient-poor, refined food. Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay. Deficiencies in many micronutrients cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo. Some of these deficiencies also cause mitochondrial decay with oxidant leakage and cellular aging and are associated with late onset diseases such as cancer. I propose DNA damage and late onset disease are consequences of a triage allocation response to micronutrient scarcity.

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Vitamin D insufficiency is common in the United States; the elderly and African-Americans are at particularly high risk of deficiency. This review, written for a broad scientific readership, presents a critical overview of scientific evidence relevant to a possible causal relationship between vitamin D deficiency and adverse cognitive or behavioural effects. Topics discussed are 1)

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As many as one-third of mutations in a gene result in the corresponding enzyme having an increased Michaelis constant, or Km, (decreased binding affinity) for a coenzyme, resulting in a lower rate of reaction. About 50 human genetic dis-eases due to defective enzymes can be remedied or ameliorated by the administration of high doses of the vitamin component of the corresponding coenzyme, which at least partially restores enzymatic activity.

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