The first retrospective cohort study of the #functional #medicine model has recently been published in the Journal of American Medical Association Network Open (#JAMA). The study saw researchers from the Cleveland Clinic’s Center for Functional Medicine examine 1,595 patients they had treated there, as well as 5,657 patients seen in primary care at a family health centre. All patients had their health-related quality of life (#QoL) assessed using a patient-reported outcomes measurement information system (#PROMIS). The National Institute of Health (#NIH) validated questionnaires, measured patients physical and mental health across a period of 12 months.

Preliminary research presented at the American Heart Association’s Scientific Sessions 2019 has shown that women who consume a higher proportion of their daily calorie intake in the evening had a greater risk of developing #cardiovascular disease. Previous studies have suggested that eating meals earlier in the day can aid weight loss, eating later may slow down #metabolism, and that later mealtimes can raise #inflammatory markers usually associated with #diabetes and #heart disease. This new research adds weight to the idea that eating more calories in the evening may negatively affect our health.

Whilst studies have previously been conducted on mice linking processed foods to #obesity and #intestinal #inflammation, human studies have been lacking. Associations have already been made regarding humans and the consumption of ultra-processed foods increasing the risks of developing obesity, #cancer, #autoimmune conditions and even premature mortality, human clinical trials have been needed to prove this link. Scientists from the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Maryland, have carried out the first study of this kind and the results showed a weight gain in as little as two weeks.

The department of Immunology from the University of Toronto have recently completed research into the origins and causes behind inflammation of the heart (#myocarditis). Whilst many other studies have been conducted, resulting in a variety of theories, there has not yet been a conclusive definition of how risk factors and environmental exposures intersect. The Toronto team have shown in their results that genetic predisposition, production of a commensal #gut #microbial #autoantigen, and systemic #inflammation combine to trigger the generation of autoreactive CD4+ T cells that cause autoimmune myocarditis and #cardiac dysfunction.

Many theories have been developed to explain why animals exhibit certain social behaviours, the impact of the #microbiota, however, has rarely been considered.  In a review published in Science Mag this month, scientists have examined several pre-clinical and clinical trials investigating the effect of the microbiota on the social brain. It has been discovered that through a diverse set of pathways the gastrointestinal microbiota is able to send signals to the brain, this is known as the #microbiota-gut-brain axis. The microbiota plays a key role in neurodevelopment from early life into adulthood influencing processes such as #neurotransmission and #neuroinflammation as well as behaviour throughout lifespan. With animals having evolved in a microbial world, these signals may have influenced the animal brain throughout evolution.

By Nathan S. Bryan, PhD, on Nitric Oxide, the Peroxynitrite Issue, and Nutritional Tools That May Help Improve Nitric Oxide Production

 Nathan S. Bryan, PhD, is an international leader in molecular medicine and nitric oxide biochemistry. Specifically, Dr. Bryan was the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He was the first to demonstrate and discover an endocrine function of nitric oxide via the formation of S-nitrosoglutathione and inorganic nitrite.

Dr. Bryan has been involved in nitric oxide research for the past 18 years, and he has made many seminal discoveries in the field. Many of these discoveries and findings have transformed the development of new therapeutic agents for the treatment and prevention of human disease.

Dr. Bryan has published a number of highly cited papers and authored or edited five books. More about his work can be found at www.drnathansbryan.com.

Experts from the University of Science and technology in Wuhan, China, have reviewed 26 studies, compiling data from 1610 participants, all investigating the efficacy of anti-inflammatory agents on major depressive disorders. The #anti-inflammatories included in the studies were non-steroidal anti-inflammatory drugs (#NSAIDs) such as #ibuprofen and #aspirin, #omega 3 fatty acids, #cytokine inhibitors, #steroids, #statins, #antibiotics, #modafinil and #N-acetyl cysteine.

The evidence for the health benefits of a varied, nutrient dense diet are vast, but new evidence has shown that by making healthy choices for our bodies we could also have a positive effect on the environment. Michael Clark from the University of Oxford led a study looking into both the health and environmental impacts of 15 different types of food groups, including fruits, vegetables, nuts, dairy, eggs, red meat, fish, olive oil, legumes and sugar-sweetened beverages. The scientists examined the food-dependent linkages between and among five diet-dependent health outcomes in adults- type II #diabetes, #stroke, #coronary heart disease, #colorectal cancer and mortality- and 5 different environmental impacts of producing the foods.

There are two main arguments to be considered when drinking #coffee, firstly its high #antioxidant status and secondly the potential risk factors associated with the #stimulant #caffeine. There have been various studies and articles written about coffee including how it can lengthen your lifespan by lowering the risk of death from several conditions including heart disease, its ability to improve memory, mood, energy and cognitive function, or how it may help the breakdown of body fat. On the other side of the argument there are reports of people suffering from dizziness, tremors and insomnia. High doses of caffeine can be linked with anxiety, digestive issues, high blood pressure and a rapid heart rate.  A new study from the American Society for Reproductive Medicine (ASRM) has caused headlines this week claiming that the occasional coffee can cause miscarriage for #pregnant women.

Earlier this year researchers from Arizona State University set out to investigate the effects of #choline on #Alzheimer’s disease (#AD). Their study focused on mice bred to display AD symptoms who were given high doses of choline in their diets. As a result of the supplementation their offspring showed improvements in spatial memory compared to those who received a normal amount of choline in the womb.  The benefits of the extra supplementation proved to be transgenerational, protecting not just the mice taking the supplement through gestation and lactation but also their future offspring. As a result of this study the same scientists began new research focusing just on female mice to see whether supplementing throughout life would reduce AD pathology and even rescue memory deficits of mice already bred to contain AD transgenes.