The Relevance of Prior Parasitic Infection and The Risk of IBS And CFS
Giardia lamblia (synonymous with Giardia intestinalis, Lamblia intestinalis and Giardia duodenalis) is a flagellated protozoan parasite that colonises and reproduces in the small intestine, causing giardiasis. The giardia parasite attaches to the epithelium by a ventral adhesive disc, and reproduces via binary fission. Giardiasis does not spread via the bloodstream, nor does it spread to other parts of the gastro-intestinal tract, but remains confined to the lumen of the small intestine.
A paper published in the esteemed journal GUT looked to see if there was a relationship between two commonly occurring conditions – IBS and CFS and giardia.
Background Giardia lamblia is a common cause of gastroenteritis worldwide, but there is limited knowledge about the long-term complications.
Objective To estimate the relative risk of irritable bowel syndrome (IBS) and chronic fatigue 3 years after acute giardiasis.
Design Controlled historic cohort study with 3 years’ follow-up. Data collected by mailed questionnaire.
Setting Waterborne outbreak of giardiasis in the city of Bergen, Norway.
Participants 817 patients exposed to Giardia lamblia infection verified by detection of cysts in stool samples and 1128 matched controls.
Main outcome measures IBS and chronic fatigue.
Results The prevalence of IBS in the exposed group was 46.1%, compared with 14.0% in the control group, and the adjusted RR=3.4 (95% CI 2.9 to 3.8). Chronic fatigue was reported by 46.1% of the exposed group and 12.0% of the controls, the adjusted RR was 4.0 (95% CI 3.5 to 4.5). IBS and chronic fatigue were associated and the RR for the exposed group of having a combination of the two outcomes was 6.8 (95% CI 5.3 to 8.5). The RR was also increased for having just one of the two syndromes, 1.8 for IBS (95% CI 1.4 to 2.3) and 2.2 for chronic fatigue (95% CI 1.7 to 2.8).
Conclusions Infection with Giardia lamblia in a non-endemic area was associated with a high prevalence of IBS and chronic fatigue 3 years after acute illness, and the risk was significantly higher than in the control group. This shows that the potential consequences of giardiasis are more serious than previously known. Further studies are needed, especially in areas where giardiasis is endemic.
As Nutritional Therapists or practitioners looking to support the recovery from infection or aid elimination of the infective agent, the role of probiotics is often explored. To determine effectiveness or proof of principle mice are sometimes used.
The probiotic Lgg Culturelle has been studies as an effective agent for the removal of giardia and whilst mice are not men this suggests there may be a role in the earlyinfective stage for a supportive supplementation with Lgg.,
 Wensaas KA, Langeland N, Hanevik K, Mørch K, Eide GE, Rortveit G. Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study. Gut. 2012 Feb;61(2):214-9. Epub 2011 Sep 12. View Article
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Thursday 19th November 2015
This evening seminar will take the gathering understanding of the role of our mitochondria as sentinels of metabolic and immune dysfunction and how lifestyle including food and food concentrates are able to either increase or decrease their viability. As our understanding of the molecular influence of food continues to grow, significant understandings become all the more important in our delivery of advice and recommendations. You may think that this subject is too esoteric or removed from every day clinical life, but never has an area of application been more relevant to almost all the clients or people that you support. Delivered in an easy to appreciate format with clinical applicability, we feel confident that this will enhance your confidence and improve your outcomes. We will be recording the event for people attending and those unable to travel..Click for further information
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