Resveratrol Acts as Potential HRT Alternative
Treatment based on resveratrol could be a safer alternative to hormone replacement therapy (HRT) in postmenopausal women and could help prevent breast cancer, according to a new study.
The findings of the study published in the Journal of Nutritional Biochemistry indicate that resveratrol is the most likely candidate of the phytoestrogens to offer safer HRT and chemoprevention of breast cancer due to its oestrogenic activity and high antitumour activity.
Phytoestrogens are natural plant substances found in food that exert weak oestrogen-like activity toward mammals, such as daidzein, genistein and glycitein found in soybeans and soy products, coumestrol in mung bean and alfalfa sprouts and resveratrol in grape skins and red wine.
Phytoestrogens have attracted attention as being safer alternatives to hormone replacement therapy (HRT) and as chemopreventive reagents for breast cancer because dietary soy isoflavone intake has been correlated with reduction in risk.
To identify safe and effective phytoestrogen candidates for HRT and breast cancer prevention, the researchers investigated the effects of daidzein, genistein, coumestrol, resveratrol and glycitein on cell growth, cell cycle, cyclin D1 expression, apoptosis, Bcl-2/Bax expression ratio and p53-dependent or NF-κB-dependent transcriptional activity in MCF-7 breast cancer cells.
They found that phytoestrogens, except for glycitein, significantly enhanced oestrogen-response-element-dependent transcriptional activity up to a level similar to that of 17β-estradiol (E2). E2 increased cell growth significantly, coumestrol increased cell growth moderately, and resveratrol and glycitein reduced cell growth.
Phytoestrogens, except for glycitein, stimulated the promotion of cells to G1/S transition in cell cycle analysis, similar to E2. This stimulation was accompanied by transient up-regulation of cyclin D1. While genistein, resveratrol and glycitein all increased apoptosis and reduced the Bcl-2/Bax ratio, resveratrol reduced this ratio more than either genistein or glycitein. Moreover, resveratrol significantly enhanced p53-dependent transcriptional activity, but slightly reduced NF-κB-dependent transcriptional activity.
On knockdown analysis, genistein, resveratrol and glycitein all reduced the Bcl-2/Bax ratio in the presence of apoptosis-inducing stimuli, and estrogen receptor (ER) α silencing had no effect on these reductions. In contrast, in the absence of apoptosis-inducing stimuli, only resveratrol reduced the ratio, and ERα silencing abolished this reduction. Thus, resveratrol might be the most promising candidate for HRT and chemoprevention of breast cancer due to its oestrogenic activity and high antitumour activity.
- Sakamoto T, Horiguchi H, Oguma E, Kayama F.J Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells. Nutr Biochem. 2009 Oct 2. [Epub ahead of print] View Abstract
- M. Gina Glazier; Marjorie A. Bowman A Review of the Evidence for the Use of Phytoestrogens as a Replacement for Traditional Estrogen Replacement Therapy Arch Intern Med. 2001;161(9):1161-1172. View Abstract View Full Paper
- Lifestyle Choices Impact Positively on Second Breast Cancer Risk
- Complementary and Alternative Medicine: Herbs, Phytochemicals and Vitamins and Their Immunologic Effects
- What Are the Preferred Methods of Detecting Breast Cancer – A Review
- Cancer Statistics, 2009. Breast Cancer rates down due to reduced risk of HRT?
- Vitamin C as a Potential Anti-Cancer Agent: Progress and Controversies
Sunday 17th January 2016
Kick start the New Year with our detoxification cookery day. Discover the key foods and nutrients to incorporate in your diet to enhance your detoxification pathways, how to remove toxins safely, signs and symptoms of toxic overload, consequences and links to long term chronic health conditions and the importance of supporting gut barrier health. This day will include practical recipes and meal planning solutions to help you plan a cleansing programme with clients together with details of the most effective supplements and nutrients to incorporate.Click for further information
Sunday 13th March 2016
In Functional Nutrition we often utilise the 5 R programme to support digestive health, restore and repair the gut barrier and tackle ongoing digestive imbalances. This practical cookery day will provide you with the resources you need to put this into action – discover the top foods to include and those to avoid, the importance of fermented foods and how to incorporate them in the diet. You will see a range of delicious recipes demonstrated to support gut healing and for lowering inflammation in the digestive tract and we will discuss different dietary approaches that may be beneficial for resolving ongoing gut symptomsClick for further information
- This evening seminar will take the gathering un...
- Psychiatric disorders in general, and major dep...
N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic ReviewFor people with obsessive compulsive disorders ...
- Dr Carrie Decker ND discusses the role of the p...
- In a clinical trial undertaken by Hudson and Ki...
Updates on your email
Don't miss out on our email updates