Is there convincing biological or behavioural evidence linking vitamin D deficiency to brain dysfunction?
Vitamin D insufficiency is common in the United States; the elderly and African-Americans are at particularly high risk of deficiency. This review, written for a broad scientific readership, presents a critical overview of scientific evidence relevant to a possible causal relationship between vitamin D deficiency and adverse cognitive or behavioural effects. Topics discussed are 1) biological functions of vitamin D relevant to cognition and behaviour; 2) studies in humans and rodents that directly examine effects of vitamin D inadequacy on cognition or behaviour; and 3) immunomodulatory activity of vitamin D relative to the proinflammatory cytokine theory of cognitive/behavioural dysfunction. We conclude there is ample biological evidence to suggest an important role for vitamin D in brain development and function. However, direct effects of vitamin D inadequacy on cognition/behaviour in human or rodent systems appear to be subtle, and in our opinion, the current experimental evidence base does not yet fully satisfy causal criteria. Possible explanations for the apparent inconsistency between results of biological and cognitive/behavioural experiments, as well as suggested areas for further research are discussed. Despite residual uncertainty, recommendations for vitamin D supplementation of at-risk groups, including nursing infants, the elderly, and African-Americans appear warranted to ensure adequacy.
McCann JC, Ames BN. Is there convincing biological or behavioural evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 2008 Apr;22(4):982-1001. Epub 2007 Dec 4. View Abstract View Full paper
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Thursday 19th November 2015
This evening seminar will take the gathering understanding of the role of our mitochondria as sentinels of metabolic and immune dysfunction and how lifestyle including food and food concentrates are able to either increase or decrease their viability. As our understanding of the molecular influence of food continues to grow, significant understandings become all the more important in our delivery of advice and recommendations. You may think that this subject is too esoteric or removed from every day clinical life, but never has an area of application been more relevant to almost all the clients or people that you support. Delivered in an easy to appreciate format with clinical applicability, we feel confident that this will enhance your confidence and improve your outcomes. We will be recording the event for people attending and those unable to travel..Click for further information
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