Is there convincing biological or behavioural evidence linking vitamin D deficiency to brain dysfunction?
Vitamin D insufficiency is common in the United States; the elderly and African-Americans are at particularly high risk of deficiency. This review, written for a broad scientific readership, presents a critical overview of scientific evidence relevant to a possible causal relationship between vitamin D deficiency and adverse cognitive or behavioural effects. Topics discussed are 1) biological functions of vitamin D relevant to cognition and behaviour; 2) studies in humans and rodents that directly examine effects of vitamin D inadequacy on cognition or behaviour; and 3) immunomodulatory activity of vitamin D relative to the proinflammatory cytokine theory of cognitive/behavioural dysfunction. We conclude there is ample biological evidence to suggest an important role for vitamin D in brain development and function. However, direct effects of vitamin D inadequacy on cognition/behaviour in human or rodent systems appear to be subtle, and in our opinion, the current experimental evidence base does not yet fully satisfy causal criteria. Possible explanations for the apparent inconsistency between results of biological and cognitive/behavioural experiments, as well as suggested areas for further research are discussed. Despite residual uncertainty, recommendations for vitamin D supplementation of at-risk groups, including nursing infants, the elderly, and African-Americans appear warranted to ensure adequacy.
McCann JC, Ames BN. Is there convincing biological or behavioural evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 2008 Apr;22(4):982-1001. Epub 2007 Dec 4. View Abstract View Full paper
- Is docosahexaenoic acid, an n–3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioural tests in humans and animals
- Clinical evidence for immunomodulatory effects of probiotic bacteria.
- Vitamin C and Hypertension in Young Women
- High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms
Sunday 13th March 2016
In Functional Nutrition we often utilise the 5 R programme to support digestive health, restore and repair the gut barrier and tackle ongoing digestive imbalances. This practical cookery day will provide you with the resources you need to put this into action – discover the top foods to include and those to avoid, the importance of fermented foods and how to incorporate them in the diet. You will see a range of delicious recipes demonstrated to support gut healing and for lowering inflammation in the digestive tract and we will discuss different dietary approaches that may be beneficial for resolving ongoing gut symptomsClick for further information
- If ever there were a perfect name for a malady,...
Clinical Pearl – Solved: The False TOA/POA Controversy Surrounding Cat’s Claw by Stephen Harrod BuhnerAs a master herbalist, he considers herbs excep...
Dietary guidance normalises large intestinal endocrine cell densities in patients with irritable bowel syndromeA research paper in the European Journal Of Cli...
Setting the Record Straight: Pre-Eminent Scientist Garth Nicolson Addresses Misinformation Disseminated by Patricia Kane, PhD Regarding NTFactor® Lipid Replacement TherapyDear Integrative Medicine Practitioners and Cli...
- Would you pay £300 for a simple bottle of ferme...
Updates on your email
Don't miss out on our email updates