Is there convincing biological or behavioural evidence linking vitamin D deficiency to brain dysfunction?
Vitamin D insufficiency is common in the United States; the elderly and African-Americans are at particularly high risk of deficiency. This review, written for a broad scientific readership, presents a critical overview of scientific evidence relevant to a possible causal relationship between vitamin D deficiency and adverse cognitive or behavioural effects. Topics discussed are 1) biological functions of vitamin D relevant to cognition and behaviour; 2) studies in humans and rodents that directly examine effects of vitamin D inadequacy on cognition or behaviour; and 3) immunomodulatory activity of vitamin D relative to the proinflammatory cytokine theory of cognitive/behavioural dysfunction. We conclude there is ample biological evidence to suggest an important role for vitamin D in brain development and function. However, direct effects of vitamin D inadequacy on cognition/behaviour in human or rodent systems appear to be subtle, and in our opinion, the current experimental evidence base does not yet fully satisfy causal criteria. Possible explanations for the apparent inconsistency between results of biological and cognitive/behavioural experiments, as well as suggested areas for further research are discussed. Despite residual uncertainty, recommendations for vitamin D supplementation of at-risk groups, including nursing infants, the elderly, and African-Americans appear warranted to ensure adequacy.
McCann JC, Ames BN. Is there convincing biological or behavioural evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 2008 Apr;22(4):982-1001. Epub 2007 Dec 4. View Abstract View Full paper
- Is docosahexaenoic acid, an n–3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioural tests in humans and animals
- Clinical evidence for immunomodulatory effects of probiotic bacteria.
- Vitamin C and Hypertension in Young Women
- High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms
1st May 2015
This evening presentation will explore the latest research and clinical applications for phytonutrients related to gene expression, disease treatment/prevention, and personalized nutrition. It will provide a foundation for clinicians to detect and diagnose phytonutrient deficiencies in their patients and offer ways to maximise daily phytonutrient intake.Click for further information
- A new study finds that when young people binge ...
Historic Artefacts, Secret Messages and Code Breakers, Undercover Organisms & Organelles and Diplomatic Relationships; Inside the World of Mucosal Immunology, Health and Disease.Historic Artefacts As complex organisms survivi...
A Meta-Analysis of the Utility of C-Reactive Protein, Erythrocyte Sedimentation Rate, Faecal Calprotectin, and Faecal Lactoferrin to Exclude Inflammatory Bowel Disease in Adults With IBS.A paper in the American Journal of Gastroentero...
- A study in Nature suggests that common food add...
Survival and Digestibility of Orally-Administered Immunoglobulin Preparations Containing Igg Through the Gastrointestinal Tract in HumansOral immunoglobulin (Ig) preparations are prime...
Updates on your email
Don't miss out on our email updates