Gastric Complications For Patients with H1N1 (Swine Flu)
The incidence of gastric events in normal seasonal flu is very low, almost never. The H1N1 swine Flu virus has differentiated itself from the seasonal flu not only in its speed of migration around the world, but also in the development of gut related events.
A new article in the International journal GUT  explains how a well set up investigational group based in Chile – a country well exposed to the virus, followed the first 500 confirmed patients who were infected with the influenza A (H1N1) 2009 virus back in May 2009.
The primary symptom was a febrile respiratory infection that varied in severity from a mild self limiting event to severe illness.
The second area of symptom dominance is in the gut – again there were significant variations in the severity and duration but worryingly some patients developed severe illness including enterocolitis. Typically this was preceded by vomiting/or diarrhoea as the main symptom in the first 12 hours.
Gastrointestinal symptoms were frequently found among Chilean patients with confirmed influenza A (H1N1) 2009 virus infection including: 72 patients with vomiting (14.3%), 147 patients with diarrhoea (29.4%) and 182 patients (36.4%) with nausea
A similar pattern was also found in the results from a North American study where 25% of confirmed H1N1 infected people had gastrointestinal problems.
The pathophysiology of these symptoms is not yet clear, but novel influenza A (H1N1) 2009 virus could be harboured in the digestive tract or a systemic inflammatory response could affect the circulatory system and/or the central nervous system, generating nausea, vomiting or diarrhoea.
The Gut is the primary site of innate immune cells and will on a typical day process more immunological information than the rest of the body does in a lifetime. The mucosal immune support programme offers practical suggestions and evidence based strategies to improve this tissues competence in resisting and managing viral infection.
References A Riquelme et al. Gastrointestinal manifestations among Chilean patients infected with novel influenza A (H1N1) 2009 virus. Gut 2009;58:1567-1568; doi:10.1136/gut.2009.194746 View Abstract  Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, Dawood FS, Jain S, Finelli L, et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009;360:2605–15. View Abstract View Full Text]
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1st May 2015
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