Dysbiosis in Autism, More Evidence Confirms Association
A paper out in PLOS this week has highlighted abnormalities in the bacterial compositions of the gut found in individuals diagnosed with autism. Whilst this is not a ground breaking a discovery as the authors suggest, it does add further qualification to the evolving recognition of the consistency of dysbiosis in individuals with autism.
This is the papers abstract.
High proportions of autistic children suffer from gastrointestinal (GI) disorders, implying a link between autism and abnormalities in gut microbial functions. Increasing evidence from recent high-throughput sequencing analyses indicates that disturbances in composition and diversity of gut microbiome are associated with various disease conditions.
However, microbiome-level studies on autism are limited and mostly focused on pathogenic bacteria. Therefore, here we aimed to define systemic changes in gut microbiome associated with autism and autism-related GI problems.
We recruited 20 neurotypical and 20 autistic children accompanied by a survey of both autistic severity and GI symptoms. By pyrosequencing the V2/V3 regions in bacterial 16S rDNA from fecal DNA samples, we compared gut microbiomes of GI symptom-free neurotypical children with those of autistic children mostly presenting GI symptoms. Unexpectedly, the presence of autistic symptoms, rather than the severity of GI symptoms, was associated with less diverse gut microbiomes.
Further, rigorous statistical tests with multiple testing corrections showed significantly lower abundances of the genera Prevotella, Coprococcus, and unclassified Veillonellaceae in autistic samples. These are intriguingly versatile carbohydrate-degrading and/or fermenting bacteria, suggesting a potential influence of unusual diet patterns observed in autistic children.
However, multivariate analyses showed that autism-related changes in both overall diversity and individual genus abundances were correlated with the presence of autistic symptoms but not with their diet patterns.
Taken together, autism and accompanying GI symptoms were characterized by distinct and less diverse gut microbial compositions with lower levels of Prevotella, Coprococcus, and unclassified Veillonellaceae.
- Maternal Immune Response to Foetal Brain During Pregnancy a Key Factor in Some Autism
- A Little Bit Of Spit Reveals A Lot About What Lives In Your Mouth
- Lessons from the Vaccine-Autism Wars
- The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders
- Herbal Components which Assist in Eradicating Dysbiosis
Sunday 17th January 2016
Kick start the New Year with our detoxification cookery day. Discover the key foods and nutrients to incorporate in your diet to enhance your detoxification pathways, how to remove toxins safely, signs and symptoms of toxic overload, consequences and links to long term chronic health conditions and the importance of supporting gut barrier health. This day will include practical recipes and meal planning solutions to help you plan a cleansing programme with clients together with details of the most effective supplements and nutrients to incorporate.Click for further information
Sunday 13th March 2016
In Functional Nutrition we often utilise the 5 R programme to support digestive health, restore and repair the gut barrier and tackle ongoing digestive imbalances. This practical cookery day will provide you with the resources you need to put this into action – discover the top foods to include and those to avoid, the importance of fermented foods and how to incorporate them in the diet. You will see a range of delicious recipes demonstrated to support gut healing and for lowering inflammation in the digestive tract and we will discuss different dietary approaches that may be beneficial for resolving ongoing gut symptomsClick for further information
- This evening seminar will take the gathering un...
- Psychiatric disorders in general, and major dep...
N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic ReviewFor people with obsessive compulsive disorders ...
- Dr Carrie Decker ND discusses the role of the p...
- In a clinical trial undertaken by Hudson and Ki...
Updates on your email
Don't miss out on our email updates