Dysbiosis in Autism, More Evidence Confirms Association
A paper out in PLOS this week has highlighted abnormalities in the bacterial compositions of the gut found in individuals diagnosed with autism. Whilst this is not a ground breaking a discovery as the authors suggest, it does add further qualification to the evolving recognition of the consistency of dysbiosis in individuals with autism.
This is the papers abstract.
High proportions of autistic children suffer from gastrointestinal (GI) disorders, implying a link between autism and abnormalities in gut microbial functions. Increasing evidence from recent high-throughput sequencing analyses indicates that disturbances in composition and diversity of gut microbiome are associated with various disease conditions.
However, microbiome-level studies on autism are limited and mostly focused on pathogenic bacteria. Therefore, here we aimed to define systemic changes in gut microbiome associated with autism and autism-related GI problems.
We recruited 20 neurotypical and 20 autistic children accompanied by a survey of both autistic severity and GI symptoms. By pyrosequencing the V2/V3 regions in bacterial 16S rDNA from fecal DNA samples, we compared gut microbiomes of GI symptom-free neurotypical children with those of autistic children mostly presenting GI symptoms. Unexpectedly, the presence of autistic symptoms, rather than the severity of GI symptoms, was associated with less diverse gut microbiomes.
Further, rigorous statistical tests with multiple testing corrections showed significantly lower abundances of the genera Prevotella, Coprococcus, and unclassified Veillonellaceae in autistic samples. These are intriguingly versatile carbohydrate-degrading and/or fermenting bacteria, suggesting a potential influence of unusual diet patterns observed in autistic children.
However, multivariate analyses showed that autism-related changes in both overall diversity and individual genus abundances were correlated with the presence of autistic symptoms but not with their diet patterns.
Taken together, autism and accompanying GI symptoms were characterized by distinct and less diverse gut microbial compositions with lower levels of Prevotella, Coprococcus, and unclassified Veillonellaceae.
4th - 8th Ocotber 2018
Applying Functional Medicine in Clinical Practice is a well-orchestrated, comprehensive, patient centered educational programme that helps you deepen your clinical understanding and practical application of the Functional Medicine Matrix ModelClick for further information
Curcumin: A Golden Remedy for Joint Health New Formulations dramatically enhance this ancient botanical’s bioavailabilityLiquid gold. Golden milk. That brilliant saffro...
- A Novel Galactofucan Sulfate Extract Enhances I...
- An Interview with Polymer Chemist Helen Fitton ...
- Join award-winning Educator, International Spea...
- As Functional Medicine practitioners, we’re awa...
Updates on your email
Don't miss out on our email updates