Detection of herpes viruses and parvovirus B19 in gastric and intestinal mucosa of chronic fatigue syndrome patients.
BACKGROUND: Human herpesvirus-6 (HHV-6), Epstein-Barr virus and parvovirus B19 have been suggested as aetiological agents of chronic fatigue syndrome but none of these viruses is consistently detected in all patients. However, active viral infections may be localised in specific tissues, and, therefore, are not easily detectable. The aim of this study was to investigate the presence of HHV-6, HHV-7, EBV and parvovirus B19 in the gastro-intestinal tract of CFS patients.
PATIENTS AND METHODS: Using real-time PCR, viral DNA loads were quantified in gastro-intestinal biopsies of 48 CFS patients and 35 controls.
RESULTS: High loads of HHV-7 DNA were detected in most CFS and control biopsies. EBV and HHV-6 were detected in 15-30% of all biopsies. Parvovirus B19 DNA was detected in 40% of the patients versus less than 15% of the controls.
CONCLUSION: Parvovirus B19 may be involved in the pathogenesis of CFS, at least for a subset of patients. The gastro-intestinal tract appears as an important reservoir of infection for several potentially pathogenic viruses.
Frémont M, Metzger K, Rady H, Hulstaert J, De Meirleir K. Detection of herpesviruses and parvovirus B19 in gastric and intestinal mucosa of chronic fatigue syndrome patients. In Vivo. 2009 Mar-Apr;23(2):209-13. View Abstract
Comment: The mucosal immune system is the site of the greatest innate immune activity in the body. The presence of dysbiosis can lead to activated cytokines and NFkB a pro inflammatory gene set of over 400 that increase inflammation. Chronic inflammation is linked with CFS including the NO-NOO cycle postulated by Dr Pall.
8th October 2016
The role of the complex community of microbial dwellers inside our digestive tract remains a valuable, but still poorly understood resource in which changes to density and variety can have significant effects on human function and health. One of the roles of these organisms is in the generation of endogenous defence molecules including the master antioxidant, glutathione.Click for further information
30th March - 3rd April 2017
Applying Functional Medicine in Clinical Practice is a well-orchestrated, comprehensive, patient centered educational programme that helps you deepen your clinical understanding and practical application of the Functional Medicine Matrix ModelClick for further information
- This learning pack is designed to explore some ...
- Antony Haynes explores the potential mechanisms...
- A paper published in the Journal of Paediatric ...
- Antony Haynes BA, RNT reviews an interesting de...
- Antony Haynes BA, RNT explores the nutritional ...
Updates on your email
Don't miss out on our email updates