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mBio150pxwide-11Now there will be those tempted to see this as a pitch for drinking more red wine….but let’s try and keep this in perspective, you see a this research looked at a compound found in red wine, resveratrol.  It found that it reduces the risk of heart disease by changing the gut microbiome, according to a new study by researchers from China. The study is published in mBio, an open-access journal published by the American Society for Microbiology.[1]

The authors are recorded as stating:

“Our results offer new insights into the mechanisms responsible for resveratrol’s anti-atherosclerosis effects and indicate that gut microbiota may become an interesting target for pharmacological or dietary interventions to decrease the risk of developing cardiovascular diseases,”

indexA fascinating open paper was published in microbiome in 2013, and its suggested conclusions are now more prescient than ever, as the relationship between genotype, phenotype, and metabolic repertoire in the microbiome is understood to be non-linear.[1] The requirement for a certain functional diversity to ensure a well-functioning cooperative intestinal microbiota is crucial to break down various complex dietary compounds and divide metabolic tasks among different community members.

molecules-logoAging is a multifactorial and tissue-specific process involving diverse alterations regarded as the “hallmarks of aging”, which include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intracellular communication.

journal_coverA research paper in the European Journal Of Clinical Nutrition published a paper looking at the effects of a low POLYOL diet on a subset of endocrine cells linked to IBS in a set of symptomatic patients. The results suggest that the diet has an effect on the cell expression.

Background/Objectives:

To determine the large intestinal endocrine cell types affected following dietary guidance in patients with irritable bowel syndrome (IBS).

indexPsychiatric disorders in general, and major depression and anxiety disorders in particular, account for a large burden of disability, morbidity and premature mortality worldwide. Omega-3 polyunsaturated fatty acids (PUFAs) have a range of neurobiological activities in modulation of neurotransmitters, anti-inflammation, anti-oxidation and neuroplasticity, which could contribute to psychotropic effects. [1]

Vitamin A and Immune Specificity

Thursday, 22 October 2015 by

eji201570050-gra-0001Homeostasis — literally ‘standing still’ — describes the mechanisms by which all biological systems maintain stability. In effect this is the position at which human health is maintained and may also be described as a homeostatic set point, in which as circumstances change so does the set point. In simple parlance the idea that someone may be in a stable state of homeostasis but one that induces illness is a concept still developing. In effect all illness generates a change in homeostasis but not all changes in homeostasis results in illness.

header-3b910cae-74f1-4559-8cef-25ede860f04eAcross the world there are chronic diseases affecting the lives of many, most of which are preventable or modifiable by appropriate lifestyle changes. Yet currently politicians are unwilling to legislate change, to force behaviours that in turn diminish the costs to the individual and to society.

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cov200hConcerns about mortality and these days morbidity settle on people’s shoulders at different times and with different weights. Some are blissfully immune to risk association with decisions and others become frozen into indecision because of fears that manifest as a result of exposure to dubious or credible sources.

Today there seems a relentless list of non-modifiable risks that provide challenges to a healthy and vibrant long life, from terrorism, economic collapse, wars, infection, pollution, agrichemicals and more. A whole industry is set up to disseminate these concerns in a relentless barrage of news, insight, opinion and at times hysteria.

cov200hPublished in the Journal Allergy and Clinical Immunology July 2015, a research paper explores the relationship between anti-inflammatory lipids in food and risk of allergic responses.[1]

The Karolinska Institute in Sweden is a world famous research centre, and scientists there explored the notion that increasing omega three fatty acids through dietary ingestion may confer benefit in a subset of people, chosen by age. Specifically they wanted to see if eating oily fish would reduce the risk of rhinitis in school children – for those of you with school children of your own, you know already that this has an effect on them, and you!

BJNThe British Journal of Nutrition published a review paper in July 2015, exploring the relationship between inflammation, diet and health. Whilst this is neither new nor novel, the momentum is becoming clear. There is a steady awareness in research that the consumption of certain foods and the absence of others contributes to a provocative change in defence molecules with the result that many of the non-communicable diseases that blight western health care can develop and thrive.

This open access article is well worth saving for those refresh reads.[1]

The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development.

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